Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines

Highlights ► The antitumor effect of free and encapsulated edelfosine is comparable in leukemia cells sensitive to the action of the drug. ► Edelfosine loaded lipid nanoparticles overcome the resistance of K562 cells to the free drug. ► Lipid nanoparticles might be triggering caspase-independent apo...

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Bibliographic Details
Published in:Cancer letters 2013-07, Vol.334 (2), p.302-310
Main Authors: Lasa-Saracíbar, Beatriz, Estella-Hermoso de Mendoza, Ander, Mollinedo, Faustino, Odero, María D, Blanco-Príeto, María J
Format: Article
Language:English
Subjects:
adverse effects
Alkyl-lysophospholipids
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Apoptosis
Apoptosis - drug effects
Aqueous solutions
Bioavailability
Cancer
Caspases - metabolism
Cell culture
Cell Line, Tumor
Chemistry, Physical
Drug Delivery Systems - methods
Drug resistance
Drug Resistance, Neoplasm
drugs
Edelfosine
encapsulation
Hematology, Oncology and Palliative Medicine
HL-60 Cells
Homogenization
Humans
K562 Cells
Leukemia
Leukemia - drug therapy
Leukemia - enzymology
Leukemia - pathology
Lipid nanoparticles
Lipids
Lipids - administration & dosage
Lipids - chemistry
Medical prognosis
Morphology
myeloid leukemia
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Phospholipid Ethers - administration & dosage
Phospholipid Ethers - chemistry
relapse
survival rate
toxicity
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Summary:Highlights ► The antitumor effect of free and encapsulated edelfosine is comparable in leukemia cells sensitive to the action of the drug. ► Edelfosine loaded lipid nanoparticles overcome the resistance of K562 cells to the free drug. ► Lipid nanoparticles might be triggering caspase-independent apoptotic pathways in resistant leukemia cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.018