Effects of Nitric Oxide on Cell Proliferation

Nitric oxide (NO) has been suggested to be a pathophysiological modulator of cell proliferation, cell cycle arrest, and apoptosis. In this context, NO can exert opposite effects under diverse conditions. Indeed, several studies have indicated that low relative concentrations of NO seem to favor cell...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2013-07, Vol.62 (2), p.89-95
Main Authors: Napoli, Claudio, MD, PhD, Paolisso, Giuseppe, MD, Casamassimi, Amelia, BiolD, Al-Omran, Mohammed, MD, Barbieri, Michelangela, MD, Sommese, Linda, BiolD, Infante, Teresa, BiolD, Ignarro, Louis J., PhD
Format: Article
Language:English
Subjects:
Apoptosis
Blood pressure
Bone marrow
Cardiology
Cardiovascular
cardiovascular diseases
Cell cycle
Cell growth
cell proliferation
diagnostic and therapeutic tools
Epidermal growth factor
Free radicals
imaging
Internal Medicine
Kinases
Nitric oxide
Nitrogen
Permeability
Phosphorylation
Proteins
Smooth muscle
Stem cells
type 2 diabetes
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Summary:Nitric oxide (NO) has been suggested to be a pathophysiological modulator of cell proliferation, cell cycle arrest, and apoptosis. In this context, NO can exert opposite effects under diverse conditions. Indeed, several studies have indicated that low relative concentrations of NO seem to favor cell proliferation and antiapoptotic responses and higher levels of NO favor pathways inducing cell cycle arrest, mitochondria respiration, senescence, or apoptosis. Here we report the effects of NO on both promotion and inhibition of cell proliferation, in particular in regard to cardiovascular disease, diabetes, and stem cells. Moreover, we focus on molecular mechanisms of action involved in the control of cell cycle progression, which include both cyclic guanosine monophosphate–dependent and –independent pathways. This growing field may lead to broad and novel targeted therapies against cardiovascular diseases, especially concomitant type 2 diabetes, as well as novel bioimaging NO-based diagnostic tools.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2013.03.070