AUTOLOGOUS STEM CELL THERAPY FOR ACUTE MYOCARDIAL INFARCTION WITH SEVERE SYSTOLIC DYSFUNCTION - PROTOCOL AND FEASIBILITY AT 1 MONTH FOLLOW-UP - BUCHAREST EXPERIENCE

The aim of this study was to assess the feasibility and safety within first month after autologous bone marrow stem cell therapy in patients with acute myocardial infarction and severe systolic dysfunction. Twelve patients were included. All the patients were treated in accordance with existing guid...

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Published in:Studia Universitatis "Vasile Goldiș". Seria ș̦tiințele vieții 2014-01, Vol.24, p.19
Main Authors: Micheu, Miruna, Oprescu, Nicoleta, Calmac, Lucian, Pitic, Daniela, Dorobantu, Maria
Format: Article
Language:English
Online Access:Get full text
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Summary:The aim of this study was to assess the feasibility and safety within first month after autologous bone marrow stem cell therapy in patients with acute myocardial infarction and severe systolic dysfunction. Twelve patients were included. All the patients were treated in accordance with existing guidelines. In the stem cell treated group, collection of 50 ml of bone marrow aspirate was performed; after density gradient separation, the mononuclear bone marrow cell suspension was delivered via intracoronary route. At 1 month follow-up, there were no significant differences between groups regarding systemic inflammatory response, malignant arrhythmias or deaths. Moreover, in stem cell treated group, the authors have observed an antiremodelling effect along with improvement of left ventricle systolic function. The autologous bone marrow stem cell therapy has proven to be a feasible and safe method of treatment, but larger studies are required in order to reveal the intimate mechanisms of action.
ISSN:1584-2363
1842-7963