Proconvulsant Effect of NUCB2/Nesfatin-1

NUCB2/nesfatin-1 has been implicated in various physiological functions such as feeding, drinking and the sleep–wake cycle, but its effect on epileptic activity is not clear. The aim of this study was to investigate the effects of NUCB2/nesfatin-1 on penicillin-induced epileptic activity and to answ...

Full description

Saved in:
Bibliographic Details
Published in:International journal of peptide research and therapeutics 2015-03, Vol.21 (1), p.29-38
Main Authors: Erken, Haydar Ali, Koç, Emine Rabia, Erken, Gülten, Genç, Osman, Çelik, Hüseyin Tuğrul, Gökçe, Emre Cemal, Ayada, Ceylan, Turgut, Sebahat, Turgut, Günfer
Format: Article
Language:English
Subjects:
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Convulsions & seizures
Electroencephalography
Epilepsy
Histology
Life Sciences
Molecular Medicine
Morphology
Penicillin
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Rodents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:NUCB2/nesfatin-1 has been implicated in various physiological functions such as feeding, drinking and the sleep–wake cycle, but its effect on epileptic activity is not clear. The aim of this study was to investigate the effects of NUCB2/nesfatin-1 on penicillin-induced epileptic activity and to answer the question of whether only NUCB2/nesfatin-1 cause epileptic activity in rats. Thirty-five rats were randomly assigned to the following seven groups: control, saline, penicillin, two different doses of NUCB2/nesfatin-1 (100 and 300 pmol), penicillin and two different doses of NUCB2/nesfatin-1 (100 and 300 pmol). EEGs were recorded before the injections and during the following 120 min. The EEG and motor findings of epileptic seizures were observed in NUCB2/nesfatin-1-injected groups. NUCB2/nesfatin-1 significantly increased the EEG power spectrum, spike frequency and amplitude values in penicillin-induced epileptic rats. These findings indicate that NUCB2/nesfatin-1 both causes epileptic activity and increases penicillin-induced epileptic activity in rats.
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-014-9428-6