Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

• Published in: Anadolu kardiyoloji dergisi : AKD 2014-02, Vol.14 (1), p.18-25
• Main Authors: Çoban, Neslihan, Onat, Altan, Kömürcü Bayrak, Evrim, Güleç, Çağrı, Can, Günay, Erginel Ünaltuna, Nihan
• Format: Article
• Language: English
• Subjects: Adult; ATP Binding Cassette Transporter 1 - genetics; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Coronary Artery Disease - blood; Coronary Artery Disease - genetics; European Continental Ancestry Group; Female; Gender Identity; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Polymorphism, Restriction Fragment Length; Risk Factors; Sex Factors; Triglycerides - blood; Turkey
• ISSN: 1302-8723; 2149-2263; 1308-0032; 2149-2271
• DOI: 10.5152/akd.2013.234

ATP binding cassette transporter A1 (ABCA1) controls the reverse cholesterol transport. Some ABCA1 variants are correlated with serum high-density lipoprotein cholesterol (HDL-C) and other lipid concentrations. We aimed to explore the relationship of ABCA1 gene with both the lipid profile and coronary heart disease (CHD) risk. Selected 627 individuals of the Turkish Adult Risk Factor Study were genotyped for ABCA1 R219K polymorphism using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method. Student's t-test, one-way ANOVA, Chi-square test, linear and logistic regression was used for statistical analysis. We demonstrated a gender-specific effect of the R219K polymorphism on plasma lipids and CHD. In men, while homozygosity of the K allele was associated with increased plasma low-density lipoprotein cholesterol (LDL-C) (p