CXCR2/CXCL5 axis contributes to epithelial–mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling

Highlights • High levels of CXCR2 correlate with progression and poor prognosis in human HCC. • High expression of CXCR2/CXCL5 together promotes metastasis of HCC cells through induction of EMT. • CXCR2/CXCL5 axis contributes to EMT through activating the PI3K/Akt/GSK-3β/Snail pathway in HCC cells....

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Bibliographic Details
Published in:Cancer letters 2015-03, Vol.358 (2), p.124-135
Main Authors: Zhou, Shao-Lai, Zhou, Zheng-Jun, Hu, Zhi-Qiang, Li, Xun, Huang, Xiao-Wu, Wang, Zheng, Fan, Jia, Dai, Zhi, Zhou, Jian
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Activation
Adult
Aged
AKT protein
Animal models
Animals
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Cell lines
Cell spreading
Cells
Chemokine CXCL5 - genetics
Chemokine CXCL5 - metabolism
CXCL5
CXCR2
CXCR2 protein
Disease Models, Animal
Disease Progression
Epithelial-Mesenchymal Transition - genetics
Epithelial–mesenchymal transition
Female
Gene Expression
Glycogen Synthase Kinase 3 - metabolism
Glycogen Synthase Kinase 3 beta
Hematology, Oncology and Palliative Medicine
Hepatocellular carcinoma
Heterografts
Humans
Immunofluorescence
Kinases
Laboratory animals
Liver cancer
Liver cirrhosis
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Medical prognosis
Mesenchyme
Metastases
Metastasis
Middle Aged
Multivariate analysis
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Phenotypes
Phosphatidylinositol 3-Kinases - metabolism
Plasmids
Prognosis
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Receptors, Interleukin-8B - genetics
Receptors, Interleukin-8B - metabolism
Regulation
Rodents
Senescence
Signal Transduction
Snail Family Transcription Factors
Therapeutic applications
Transcription Factors - metabolism
Tumor Burden
Tumor cells
Tumorigenesis
Xenografts
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Summary:Highlights • High levels of CXCR2 correlate with progression and poor prognosis in human HCC. • High expression of CXCR2/CXCL5 together promotes metastasis of HCC cells through induction of EMT. • CXCR2/CXCL5 axis contributes to EMT through activating the PI3K/Akt/GSK-3β/Snail pathway in HCC cells. • High levels of CXCR2/CXCL5 correlates with the activation of PI3K/Akt/GSK-3β/Snail pathway and EMT phenotype in HCC patients.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.11.044