An ERK/Cdk5 axis controls the diabetogenic actions of PPAR[gamma]

Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPAR[gamma].

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Bibliographic Details
Published in:Nature (London) 2015-01, Vol.517 (7534), p.391
Main Authors: Banks, Alexander S, McAllister, Fiona E, Camporez, João Paulo G, Zushin, Peter-James H, Jurczak, Michael J, Laznik-Bogoslavski, Dina, Shulman, Gerald I, Gygi, Steven P, Spiegelman, Bruce M
Format: Article
Language:English
Subjects:
Adipose tissue
Cell receptors
Cellular signal transduction
Diabetes
Glucose
Insulin
Insulin resistance
Kinases
Obesity
Peroxisomes
Physiological aspects
Physiological research
Protein kinases
Rodents
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Description
Summary:Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPAR[gamma].
ISSN:0028-0836
1476-4687
DOI:10.1038/nature13887