The decreased frequency of SIGIRR-positive CD4+ T cells in peripheral blood of patients with SLE and its correlation with disease activity

Recently, many studies have shown that Single immunoglobulin interleukin-1 receptor related protein (SIGIRR), a member of the IL-1R family acting as a negative regulator of TLR/IL-1R signaling, affects autoimmune responses in animal model of systemic lupus erythematosus (SLE). However, the role of S...

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Bibliographic Details
Published in:Molecular biology reports 2015-02, Vol.42 (2), p.423-430
Main Authors: Wang, Dao-Yang, Su, Chao, Chen, Gui-Mei, Pan, Hai-Feng, Wang, Feng-Mei, Liu, Gui-Ling, Hao, Li, Wang, De-Guang, Ye, Dong-Qing
Format: Article
Language:English
Subjects:
Adult
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Case-Control Studies
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cellular biology
Female
Flow Cytometry
Glucocorticoids - therapeutic use
Histology
Humans
Immunosuppressive Agents - therapeutic use
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Life Sciences
Lupus
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - metabolism
Male
Molecular biology
Morphology
Pathogenesis
Proteins
Receptors, Interleukin-1 - metabolism
Severity of Illness Index
Young Adult
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Summary:Recently, many studies have shown that Single immunoglobulin interleukin-1 receptor related protein (SIGIRR), a member of the IL-1R family acting as a negative regulator of TLR/IL-1R signaling, affects autoimmune responses in animal model of systemic lupus erythematosus (SLE). However, the role of SIGIRR in the pathogenesis of human SLE has not been widely explored. In this study, we analyzed the frequency of SIGIRR-positive CD4+ T cells in peripheral blood mononuclear cells (PBMCs) of SLE patients and its correlation with disease activity as well as the clinical data. Circulating SIGIRR-positive CD4+ T cells were quantified in 51 SLE patients and 38 healthy controls by using flow cytometer. Results showed that the percentages of SIGIRR-positive CD4+ T cells were decreased in the PBMCs of SLE patients compared with healthy controls ( Z  = −5.49, P  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-014-3783-4