Primary central nervous system histiocytic sarcoma mimicking glioma

Magnetic resonance imaging (MRI) [Figure 1] revealed an irregular intra-axial mass in the frontal lobe with significant peri-lesional edema. [4] Immunohistochemically, the tumor cells were positive for CD68 and lysozyme [Figure 2]b and c. The cells were also focally positive for S-100 and vimentin b...

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Bibliographic Details
Published in:Neurology India 2014-11, Vol.62 (6), p.684
Main Authors: Bai, Jiwei, Li, Guang, Shen, Mi, Sui, Dali, Lin, Song
Format: Article
Language:English
Subjects:
Brain Neoplasms - pathology
Care and treatment
Case studies
Chemotherapy
Diagnosis
Diagnosis, Differential
Glioma - pathology
Gliomas
Histiocytic Sarcoma - pathology
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
Nervous system
Radiation therapy
Sarcoma
Surgery
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Summary:Magnetic resonance imaging (MRI) [Figure 1] revealed an irregular intra-axial mass in the frontal lobe with significant peri-lesional edema. [4] Immunohistochemically, the tumor cells were positive for CD68 and lysozyme [Figure 2]b and c. The cells were also focally positive for S-100 and vimentin but negative for EMA, CK, GFAP, LCA, myoglobin, synaptophysin, Melan A, HMB45, ALK, desmin, CD15, CD30, CD1a, CD21, CD45RO, CD38, CD138, CD99, CD56, MAP-2 and Olig2. [...]preoperative diagnosis of CNS HS is challenging.
ISSN:0028-3886
1998-4022
DOI:10.4103/0028-3886.149409