Salt and gene expression: evidence for [Na^sup +^]^sub i^/[K^sup +^]^sub i^-mediated signaling pathways

Issue Title: SALT Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]^sub i^/[K+]^sub i^). Side-by-side with sensing of osmolality elevation by ton...

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Bibliographic Details
Published in:Pflügers Archiv 2015-03, Vol.467 (3), p.489
Main Authors: Orlov, Sergei N, Hamet, Pavel
Format: Article
Language:English
Online Access:Get full text
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Summary:Issue Title: SALT Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]^sub i^/[K+]^sub i^). Side-by-side with sensing of osmolality elevation by tonicity enhancer-binding protein (TonEBP, NFAT5), [Na+]^sub i^/[K+]^sub i^-mediated excitation-transcription coupling may contribute to the transcriptomic changes evoked by high salt consumption. This novel mechanism includes the sensing of heightened Na+ concentration in the plasma, interstitial, and cerebrospinal fluids via augmented Na+ influx in the endothelium, immune system cells, and the subfornical organ, respectively. In these cells, [Na+]^sub i^/[K+]^sub i^ ratio elevation, triggered by augmented Na+ influx, is further potentiated by increased production of endogenous Na+,K+-ATPase inhibitors documented in salt-sensitive hypertension.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-014-1650-8