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Chemoradiation in elderly patients with head and neck cancers: a single institution experience

Abstract Aims To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with head and neck cancers aged 65 and older. Materials and methods Thirty-two elderly patients were treated with radical chemoradiation. Twenty-six (81.3%) out of thirty-two patients had stage III–IV diseas...

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Published in:American journal of otolaryngology 2015-03, Vol.36 (2), p.117-121
Main Authors: Kataria, Tejinder, MD, DNB, Gupta, Deepak, MD, Bisht, Shyam Singh, MD, Goyal, Shikha, MD, DNB, Basu, Trinanjan, MD, Srivastava, Anurita, MD, DNB, Abhishek, Ashu, MD, HB, Govardhan, MD, DNB, Sharma, Kuldeep, MD, DNB, Kumar, Vikash, MD
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Language:English
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Summary:Abstract Aims To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with head and neck cancers aged 65 and older. Materials and methods Thirty-two elderly patients were treated with radical chemoradiation. Twenty-six (81.3%) out of thirty-two patients had stage III–IV disease. Twenty-nine (90.6%) patients received concurrent weekly cisplatin or carboplatin, 3 (9.4%) patients received concurrent cetuximab or nimotuzumab. Total dose of radiotherapy ranged from 66 Gy to 70 Gy. Results Twenty-nine patients (90.6%) completed at least 5 cycles of concurrent chemotherapy. Twenty-four (77.6%) patients achieved complete response. Fourteen (45.2%) patients experienced grade 3 mucositis. None of our patients developed grade 3 or above hematological toxicity. Loco-regional control and overall survival at 2 year were 71.6% and 88.9%, respectively. Conclusions Chemoradiation in elderly patients with high precision radiotherapy is a feasible option.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2014.07.015