Relative effects of heavy alcohol use and Hepatitis C in decompensated chronic liver disease in a hospital inpatient population

Abstract Background: Heavy alcohol use has been hypothesized to accelerate disease progression to end-stage liver disease in patients with hepatitis C virus (HCV) infection. In this study, we estimated the relative influences of heavy alcohol use and HCV in decompensated chronic liver disease (CLD)....

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Bibliographic Details
Published in:The American journal of drug and alcohol abuse 2015-03, Vol.41 (2), p.177-182
Main Authors: Mankal, Pavan Kumar, Abed, Jean, Aristy, Jose David, Munot, Khushboo, Suneja, Upma, Engelson, Ellen S., Kotler, Donald P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alcohol
Alcohol Abuse
Alcohol use
Alcoholism - complications
Alcoholism - pathology
ascites
Blood Diseases
Blood Pressure
cirrhosis
Cross-Sectional Studies
Disease Progression
Diseases
Drinking Behavior
end stage liver disease
Female
Graphs
Hepatic Encephalopathy - complications
Hepatic Encephalopathy - pathology
Hepatitis
Hepatitis C
Hepatitis C - complications
Hepatitis C - pathology
Hospitals
Humans
Inpatient care
Inpatients
Liver cirrhosis
Liver diseases
Liver Failure - complications
Liver Failure - pathology
Male
Middle Aged
Patients
Retrospective Studies
Risk
varices
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Summary:Abstract Background: Heavy alcohol use has been hypothesized to accelerate disease progression to end-stage liver disease in patients with hepatitis C virus (HCV) infection. In this study, we estimated the relative influences of heavy alcohol use and HCV in decompensated chronic liver disease (CLD). Methods: Retrospectively, 904 patients with cirrhotic disease admitted to our hospitals during January 2010-December 2012 were identified based on ICD9 codes. A thorough chart review captured information on demographics, viral hepatitis status, alcohol use and progression of liver disease (i.e. decompensation). Decompensation was defined as the presence of ascites due to portal hypertension, bleeding esophageal varices, hepatic encephalopathy or hepatorenal syndrome. Heavy alcohol use was defined as a chart entry of greater than six daily units of alcohol or its equivalent. Results: 347 patients were included based on our selection criteria of documented heavy alcohol use (n = 215; 62.0%), hepatitis titers (HCV: n = 182; 52.5%) and radiological evidence of CLD with or without decompensation (decompensation: n = 225; 64.8%). Independent of HCV infection, heavy alcohol use significantly increased the risk of decompensation (OR = 1.75, 95% CI 1.11-2.75, p 
ISSN:0095-2990
1097-9891
DOI:10.3109/00952990.2014.964358