Visible-Light-Photocatalyzed Metal-Free C-H Heteroarylation of Heteroarenes at Room Temperature: A Sustainable Synthesis of Biheteroaryls

An efficient C–H heteroarylation of heteroarenes is achieved through visible‐light photoredox‐catalyzed diazotization of heteroarylamines in situ by tBuONO at room temperature. A library of functionalized biheteroaryls is obtained by using this protocol. The reaction avoids the use of transition‐met...

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Bibliographic Details
Published in:European journal of organic chemistry 2015-03, Vol.2015 (8), p.1727-1734
Main Authors: Maity, Pintu, Kundu, Debasish, Ranu, Brindaban C.
Format: Article
Language:English
Subjects:
C-H heteroarylation
Cross-coupling
Heterocycles
Photochemistry
Radical reactions
Synthetic methods
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Summary:An efficient C–H heteroarylation of heteroarenes is achieved through visible‐light photoredox‐catalyzed diazotization of heteroarylamines in situ by tBuONO at room temperature. A library of functionalized biheteroaryls is obtained by using this protocol. The reaction avoids the use of transition‐metal catalysts, additives, and acidic reaction medium. An efficient C–H heteroarylation of heteroarenes is achieved through visible‐light photoredox‐catalyzed diazotization of heteroarylamines in situ by tBuONO at room temperature in the absence of any transition metal, additive, or acid. The approach gives access to a library of functionalized biheteroaryls.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500006