sup 1^H, ^sup 15^N and ^sup 13^C resonance assignments and secondary structure prediction of Q4D059, a conserved and kinetoplastid-specific hypothetical protein from Trypanosoma cruzi

Trypanosoma cruzi is a human parasite that causes Chagas disease, an illness affecting millions of people and without an efficient treatment available. Sequencing the pathogen genome has revealed that near half of protein-coding genes correspond to hypothetical proteins of unknown function, increasi...

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Bibliographic Details
Published in:Biomolecular NMR assignments 2015-04, Vol.9 (1), p.161
Main Authors: López-castilla, Aracelys, de Menezes, Rachel S, D' Andrea, Éverton D, Dos Santos, Thamires R, Pires, José R
Format: Article
Language:English
Subjects:
Hypothesis testing
NMR
Nuclear magnetic resonance
Parasites
Proteins
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Summary:Trypanosoma cruzi is a human parasite that causes Chagas disease, an illness affecting millions of people and without an efficient treatment available. Sequencing the pathogen genome has revealed that near half of protein-coding genes correspond to hypothetical proteins of unknown function, increasing the possibilities for novel target discovery. Q4D059 is a putative essential hypothetical protein from T. cruzi and it is specific and conserved among the trypanosomatid genomes. Here, we report the sequential backbone and side chain resonance assignments and secondary structure analysis of Q4D059, as first step for protein structure determination, function elucidation and drug screening.
ISSN:1874-2718
1874-270X
DOI:10.1007/s12104-014-9565-z