Drug-resistant tuberculosis in HIV-infected patients in a national referral hospital, Phnom Penh, Cambodia

There are no recent data on the prevalence of drug-resistant tuberculosis (DR TB) in Cambodia. We aim to describe TB drug resistance amongst adults with pulmonary and extra-pulmonary TB and human immunodeficiency virus (HIV) co-infection in a national referral hospital in Phnom Penh, Cambodia. Betwe...

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Bibliographic Details
Published in:Global health action 2015-01, Vol.8 (1), p.25964-25964
Main Authors: Walls, Genevieve, Bulifon, Sophie, Breysse, Serge, Daneth, Thol, Bonnet, Maryline, Hurtado, Northan, Molfino, Lucas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anti-Retroviral Agents - therapeutic use
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Cambodia
Cambodia - epidemiology
Coinfection
Culture
Data collection
Drug resistance
drug resistant
Feasibility
Female
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
Hospitals
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Laboratories
Male
Medical diagnosis
Medical treatment
Microscopy
Middle Aged
Mortality
Multidrug resistant organisms
Original
Patients
Population
Prevalence
Socioeconomic Factors
Susceptibility
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Young Adult
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Summary:There are no recent data on the prevalence of drug-resistant tuberculosis (DR TB) in Cambodia. We aim to describe TB drug resistance amongst adults with pulmonary and extra-pulmonary TB and human immunodeficiency virus (HIV) co-infection in a national referral hospital in Phnom Penh, Cambodia. Between 22 November 2007 and 30 November 2009, clinical specimens from HIV-infected patients suspected of having TB underwent routine microscopy, Mycobacterium tuberculosis culture, and drug susceptibility testing. Laboratory and clinical data were collected for patients with positive M. tuberculosis cultures. M. tuberculosis was cultured from 236 HIV-infected patients. Resistance to any first-line TB drug occurred in 34.7% of patients; 8.1% had multidrug resistant tuberculosis (MDR TB). The proportion of MDR TB amongst new patients and previously treated patients was 3.7 and 28.9%, respectively (p
ISSN:1654-9716
1654-9880
1654-9880
DOI:10.3402/gha.v8.25964