Osteoprotegerin: a valid new marker of bone turnover in post-menopausal osteoporosis?

An increase of setum osteoprotegerin has been found in post-menopausal women, that is positively correlated with age and bone markers, negatively with bone mass. In 25 post-menopausal women (mean age, 63±8 years) we measured serum levels of osteoprotegerin, total and bone alkaline phosphatase, osteo...

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Bibliographic Details
Published in:Journal of orthopaedics and traumatology 2005-06, Vol.6 (2), p.88-90
Main Authors: Ulivieri, F. M., Piodi, L. P., Marchelli, D., Corradini, C., Verdoia, C., Gerundini Gherardi, P.
Format: Article
Language:English
Subjects:
Bone density
Older people
Osteoporosis
Phosphatase
Women
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Summary:An increase of setum osteoprotegerin has been found in post-menopausal women, that is positively correlated with age and bone markers, negatively with bone mass. In 25 post-menopausal women (mean age, 63±8 years) we measured serum levels of osteoprotegerin, total and bone alkaline phosphatase, osteocalcin, urinary deoxypyridinoline and bone mineral density of the lumbar spine and femur. Osteoprotegerin and bone markers did not differ from range of normal values. Bone mineral density appeared markedly reduced both at the spine and the femur. A significant correlation between osteoprotegerin and age, duration of menopause, osteocalcin and bone alkaline phosphatase was found. No correlation was found between osteoprotegerin and bone mineral density in all measured skeletal sites. In conclusion, osteoprotegerin does not appear to be an interesting parameter for the evaluation of bone turnover in post-menopausal osteoporosis.[PUBLICATION ABSTRACT]
ISSN:1590-9921
1590-9999
DOI:10.1007/s10195-005-0087-4