Backscattered electron microscopy evidences tight apposition between bone and bioactive glass coating in vivo

AbstractThe rationale for a degradable bioactive glass coating is to lead the bone to appose gradually to the metal. A bioactive glass already described in the literature (bg A) and a sodium-calcium-silicate non-bioactive glass sprayed as a control were studied. Young adult New Zealand White rabbits...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedics and traumatology 2005-12, Vol.6 (4), p.179-182
Main Authors: Merolli, A., Giannotta, L., Gabbi, C., Cacchioli, A., Tranquilli Leali, P.
Format: Article
Language:English
Subjects:
Animal models
Apposition
Backscattering
Bioglass
Biological activity
Bone remodeling
Bone resorption
Coatings
Electron microscopy
Fish
Glass coatings
Grooves
Microscopy
Rabbits
Young adults
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AbstractThe rationale for a degradable bioactive glass coating is to lead the bone to appose gradually to the metal. A bioactive glass already described in the literature (bg A) and a sodium-calcium-silicate non-bioactive glass sprayed as a control were studied. Young adult New Zealand White rabbits were selected as animal model. A hole was drilled from the femural intercondylar groove and Ti6Al4Vcoated cylinders were implanted. Retrieval took place at 1, 2, 4, 6, 8 and 10 months and samples were analyzed by backscattered electron microscopy (BSEM). For all the samples of bioactive glass, bone was in tight apposition with the coating. As time progressed, bone showed characters of physiological remodelling (newly formed bone substituting areas of bone resorption) close to the coating. At the interface between bone and bioactive glass coating, the apposition was so tight that it was not possible to discern a clear demarcation, even at higher BSEM magnification. A second key feature, in the behavior of the bioactive glass coatings invivo, was the gradual degradation and the eventual apposition of bone directly to Ti6Al4V.
ISSN:1590-9921
1590-9999
DOI:10.1007/s10195-005-0105-6