FLIP: A flop for execution signals

Highlights ► Resistance to death receptor induced apoptosis. ► cFLIP expression induces death resistance. ► cFLIP as a target for anti-cancer drug development.

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Bibliographic Details
Published in:Cancer letters 2013-05, Vol.332 (2), p.151-155
Main Authors: Subramaniam, Kothandharaman, Hirpara, Jayshree L, Tucker-Kellogg, Lisa, Tucker-Kellogg, Greg, Pervaiz, Shazib
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Apoptosis
Binding sites
Cancer
carcinogenesis
CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism
Caspase 8 - metabolism
caspase-8
Cell Proliferation
cFLIP
chemotherapy
cytosol
death
drugs
Gene Expression Regulation, Neoplastic
Genome
Genome, Human
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Medical research
neoplasms
Neoplasms - metabolism
nucleotide sequences
Promoter Regions, Genetic
Protein Isoforms
proteins
Signal Transduction
transcription (genetics)
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Description
Summary:Highlights ► Resistance to death receptor induced apoptosis. ► cFLIP expression induces death resistance. ► cFLIP as a target for anti-cancer drug development.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.07.005