DABIGATRAN ABROGATES BRAIN ENDOTHELIAL CELL PERMEABILITY IN RESPONSE TO THROMBIN

Since thrombin has been implicated in vascular injury during ischemia, we hypothesized that dabigatran could decrease the risk of intracerebral hemorrhage by direct inhibition of thrombin-induced permeability via protection of β1 integrin.

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2013-03, Vol.61 (10), p.E2043-E2043
Main Authors: Hawkins, Brian T, Gu, Yu–Huan, Izawa, Yoshikane, Zoppo, Gregory J. del
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Internal Medicine
Ischemia
Medical research
Permeability
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since thrombin has been implicated in vascular injury during ischemia, we hypothesized that dabigatran could decrease the risk of intracerebral hemorrhage by direct inhibition of thrombin-induced permeability via protection of β1 integrin.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(13)62043-4