Gentamicin trough levels using a simplified extended-interval dosing regimen in preterm and term newborns

To evaluate a simplified gentamicin extended-interval dosing regimen in a large cohort of preterm and term newborns, we conducted a retrospective cohort study over a 4-year period. All inborn newborns who received gentamicin for the first episode of suspected or proven sepsis were eligible. Newborns...

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Bibliographic Details
Published in:European journal of pediatrics 2015-05, Vol.174 (5), p.669-673
Main Authors: König, Kai, Lim, Angelina, Miller, Anne, Saker, Suzanne, Guy, Katelyn J., Barfield, Charles P.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Birth weight
Cohort analysis
Drug dosages
Gentamicins - administration & dosage
Gestational age
Humans
Infant, Newborn
Infant, Premature
Intensive care
Medical errors
Medicine
Medicine & Public Health
Newborn babies
Original Article
Pediatrics
Premature babies
Retrospective Studies
Sepsis
Sepsis - drug therapy
Term Birth
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Summary:To evaluate a simplified gentamicin extended-interval dosing regimen in a large cohort of preterm and term newborns, we conducted a retrospective cohort study over a 4-year period. All inborn newborns who received gentamicin for the first episode of suspected or proven sepsis were eligible. Newborns received 4 mg/kg gentamicin intravenously 24-hourly, except for those at 2 μg/mL. Indomethacin co-medication significantly increased the median gentamicin trough level in preterm infants at
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-014-2450-z