A SPECIFIC ANTIDOTE FOR TICAGRELOR

Conclusion: MEDI2452 1) Specifically binds to ticagrelor and TAM with high affinity, 2) Concentration dependently neutralizes the plasma unbound fraction of ticagrelor and reverses ticagrelor and TAM mediated inhibition of platelet aggregation in vitro and 3) Rapidly and effectively reverses platele...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-03, Vol.65 (10), p.A253-A253
Main Authors: Nylander, Sven, Pehrsson, Susanne, Inghardt, Tord, Antonsson, Thomas, Svensson, Peder, Sjögren, Tove, Öster, Linda, Janefeldt, Annika, Sandinge, Ann-Sofie, Newton, Phil, Keyes, Feenagh, Austin, Mark, Buchanan, Andrew
Format: Article
Language:English
Subjects:
Blood platelets
Cardiology
Cardiovascular
Internal Medicine
Plasma
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Summary:Conclusion: MEDI2452 1) Specifically binds to ticagrelor and TAM with high affinity, 2) Concentration dependently neutralizes the plasma unbound fraction of ticagrelor and reverses ticagrelor and TAM mediated inhibition of platelet aggregation in vitro and 3) Rapidly and effectively reverses platelet aggregation when given to ticagrelor treated mice.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)60253-4