THE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST FINGOLIMOD REDUCES MYOCARDIAL ISCHEMIA-REPERFUSION INJURY MEDIATED BY ACTIVATION OF AUTOPHAGY: AN IN VITRO AND IN VIVO STUDY

Background: Autophagy (the cellular process responsible for the degradation and recycling of damaged proteins and organelles) is a downstream pathway which plays a role in decreasing ischemia-reperfusion (I-R) injury.

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-03, Vol.65 (10), p.A796-A796
Main Authors: Santos-Gallego, Carlos G, Picatoste, Belen, Njerve, Ida U, Vahl, Torsten, Ishikawa, Kiyotake, Hajjar, Roger, Fuster, Valentin, Badimon, Juan
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Cardiology
Cardiomyocytes
Cardiovascular
Heart attacks
Internal Medicine
Ischemia
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Description
Summary:Background: Autophagy (the cellular process responsible for the degradation and recycling of damaged proteins and organelles) is a downstream pathway which plays a role in decreasing ischemia-reperfusion (I-R) injury.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)60796-3