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CGM-measured glucose values have a strong correlation with C-peptide, HbA^sub 1c^ and IDAAC, but do poorly in predicting C-peptide levels in the two years following onset of diabetes
The aim of this work was to assess the association between continuous glucose monitoring (CGM) data, HbA^sub 1c^, insulin-dose-adjusted HbA^sub 1c^ (IDAA^sub 1c^) and C-peptide responses during the first 2 years following diagnosis of type 1 diabetes. A secondary analysis was conducted of data colle...
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Published in: | Diabetologia 2015-06, Vol.58 (6), p.1167 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The aim of this work was to assess the association between continuous glucose monitoring (CGM) data, HbA^sub 1c^, insulin-dose-adjusted HbA^sub 1c^ (IDAA^sub 1c^) and C-peptide responses during the first 2 years following diagnosis of type 1 diabetes. A secondary analysis was conducted of data collected from a randomised trial assessing the effect of intensive management initiated within 1 week of diagnosis of type 1 diabetes, in which mixed-meal tolerance tests were performed at baseline and at eight additional time points through 24 months. CGM data were collected at each visit. Among 67 study participants (mean age [± SD] 13.3±5.7 years), HbA^sub 1c^ was inversely correlated with C-peptide at each time point (p |
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ISSN: | 0012-186X 1432-0428 |
DOI: | 10.1007/s00125-015-3559-y |