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CGM-measured glucose values have a strong correlation with C-peptide, HbA^sub 1c^ and IDAAC, but do poorly in predicting C-peptide levels in the two years following onset of diabetes

The aim of this work was to assess the association between continuous glucose monitoring (CGM) data, HbA^sub 1c^, insulin-dose-adjusted HbA^sub 1c^ (IDAA^sub 1c^) and C-peptide responses during the first 2 years following diagnosis of type 1 diabetes. A secondary analysis was conducted of data colle...

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Bibliographic Details
Published in:Diabetologia 2015-06, Vol.58 (6), p.1167
Main Authors: Buckingham, Bruce, Cheng, Peiyao, Beck, Roy W, Kollman, Craig, Ruedy, Katrina J, Weinzimer, Stuart A, Slover, Robert, Bremer, Andrew A, Fuqua, John, Tamborlane, William
Format: Article
Language:English
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Summary:The aim of this work was to assess the association between continuous glucose monitoring (CGM) data, HbA^sub 1c^, insulin-dose-adjusted HbA^sub 1c^ (IDAA^sub 1c^) and C-peptide responses during the first 2 years following diagnosis of type 1 diabetes. A secondary analysis was conducted of data collected from a randomised trial assessing the effect of intensive management initiated within 1 week of diagnosis of type 1 diabetes, in which mixed-meal tolerance tests were performed at baseline and at eight additional time points through 24 months. CGM data were collected at each visit. Among 67 study participants (mean age [± SD] 13.3±5.7 years), HbA^sub 1c^ was inversely correlated with C-peptide at each time point (p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-015-3559-y