Adults with Long-Duration Type 2 Diabetes Have Blunted Glycemic and [Beta]-Cell Function Improvements After Bariatric Surgery

This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery. Twenty-seven adults with short- (

Saved in:
Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2015-03, Vol.23 (3), p.523
Main Authors: Khanna, Vishesh, Malin, Steven K, Bena, James, Abood, Beth, Pothier, Claire E, Bhatt, Deepak L, Nissen, Steven, Watanabe, Richard, Brethauer, Stacy A, Schauer, Philip R, Kirwan, John P, Kashyap, Sangeeta R
Format: Article
Language:English
Subjects:
Glucose
Hyperglycemia
Insulin
Obesity
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 3
container_start_page 523
container_title Obesity (Silver Spring, Md.)
container_volume 23
creator Khanna, Vishesh
Malin, Steven K
Bena, James
Abood, Beth
Pothier, Claire E
Bhatt, Deepak L
Nissen, Steven
Watanabe, Richard
Brethauer, Stacy A
Schauer, Philip R
Kirwan, John P
Kashyap, Sangeeta R
description This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery. Twenty-seven adults with short- (
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1678722602</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3675207041</sourcerecordid><originalsourceid>FETCH-proquest_journals_16787226023</originalsourceid><addsrcrecordid>eNqNjMtqwzAUREVJoUnaf7jQtUG2Uz-Wdt7QXbMIhBJU-9qVkeVUukrwIv9eE0rWXc3AnDMPbOynIffiMN2P7j3xn9jE2obzWcTf_DG7ZqVTZOEi6RveO117C2cEyU7Drj8hBLCQ4gsJLWzEGSFXThOWsFZ9ga0sQOgSDjmS-PTmqBSsnC5u-rY9me6MLerhPqsIDeTCSEFmsD6cqdH0z-yxEsriy19O2etquZtvvEH9cWjp2HTO6GE6-lGcxEEQ8SD8H_ULxldQEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1678722602</pqid></control><display><type>article</type><title>Adults with Long-Duration Type 2 Diabetes Have Blunted Glycemic and [Beta]-Cell Function Improvements After Bariatric Surgery</title><source>Wiley</source><creator>Khanna, Vishesh ; Malin, Steven K ; Bena, James ; Abood, Beth ; Pothier, Claire E ; Bhatt, Deepak L ; Nissen, Steven ; Watanabe, Richard ; Brethauer, Stacy A ; Schauer, Philip R ; Kirwan, John P ; Kashyap, Sangeeta R</creator><creatorcontrib>Khanna, Vishesh ; Malin, Steven K ; Bena, James ; Abood, Beth ; Pothier, Claire E ; Bhatt, Deepak L ; Nissen, Steven ; Watanabe, Richard ; Brethauer, Stacy A ; Schauer, Philip R ; Kirwan, John P ; Kashyap, Sangeeta R</creatorcontrib><description>This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery. Twenty-seven adults with short- (&lt;5 years) and long-duration (≥10 years) type 2 diabetes received a mixed-meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first- and second-phase meal-stimulated insulin secretion, disposition index (i.e., DI or pancreatic β-cell function), and incretin responses were examined. Adults with short-duration type 2 diabetes had better HbA^sub 1c^, greater insulin secretory capacity, and greater DI compared with adults with long-duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA^sub 1c^ and DI but not weight loss. Enhanced β-cell function characterizes the effect of bariatric surgery in adults with diabetes for &lt;5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long-standing type 2 diabetes.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><language>eng</language><publisher>Silver Spring: Blackwell Publishing Ltd</publisher><subject>Glucose ; Hyperglycemia ; Insulin ; Obesity ; Rodents</subject><ispartof>Obesity (Silver Spring, Md.), 2015-03, Vol.23 (3), p.523</ispartof><rights>Copyright Blackwell Publishing Ltd. Mar 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Khanna, Vishesh</creatorcontrib><creatorcontrib>Malin, Steven K</creatorcontrib><creatorcontrib>Bena, James</creatorcontrib><creatorcontrib>Abood, Beth</creatorcontrib><creatorcontrib>Pothier, Claire E</creatorcontrib><creatorcontrib>Bhatt, Deepak L</creatorcontrib><creatorcontrib>Nissen, Steven</creatorcontrib><creatorcontrib>Watanabe, Richard</creatorcontrib><creatorcontrib>Brethauer, Stacy A</creatorcontrib><creatorcontrib>Schauer, Philip R</creatorcontrib><creatorcontrib>Kirwan, John P</creatorcontrib><creatorcontrib>Kashyap, Sangeeta R</creatorcontrib><title>Adults with Long-Duration Type 2 Diabetes Have Blunted Glycemic and [Beta]-Cell Function Improvements After Bariatric Surgery</title><title>Obesity (Silver Spring, Md.)</title><description>This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery. Twenty-seven adults with short- (&lt;5 years) and long-duration (≥10 years) type 2 diabetes received a mixed-meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first- and second-phase meal-stimulated insulin secretion, disposition index (i.e., DI or pancreatic β-cell function), and incretin responses were examined. Adults with short-duration type 2 diabetes had better HbA^sub 1c^, greater insulin secretory capacity, and greater DI compared with adults with long-duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA^sub 1c^ and DI but not weight loss. Enhanced β-cell function characterizes the effect of bariatric surgery in adults with diabetes for &lt;5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long-standing type 2 diabetes.</description><subject>Glucose</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Obesity</subject><subject>Rodents</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNjMtqwzAUREVJoUnaf7jQtUG2Uz-Wdt7QXbMIhBJU-9qVkeVUukrwIv9eE0rWXc3AnDMPbOynIffiMN2P7j3xn9jE2obzWcTf_DG7ZqVTZOEi6RveO117C2cEyU7Drj8hBLCQ4gsJLWzEGSFXThOWsFZ9ga0sQOgSDjmS-PTmqBSsnC5u-rY9me6MLerhPqsIDeTCSEFmsD6cqdH0z-yxEsriy19O2etquZtvvEH9cWjp2HTO6GE6-lGcxEEQ8SD8H_ULxldQEw</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Khanna, Vishesh</creator><creator>Malin, Steven K</creator><creator>Bena, James</creator><creator>Abood, Beth</creator><creator>Pothier, Claire E</creator><creator>Bhatt, Deepak L</creator><creator>Nissen, Steven</creator><creator>Watanabe, Richard</creator><creator>Brethauer, Stacy A</creator><creator>Schauer, Philip R</creator><creator>Kirwan, John P</creator><creator>Kashyap, Sangeeta R</creator><general>Blackwell Publishing Ltd</general><scope>K9.</scope></search><sort><creationdate>20150301</creationdate><title>Adults with Long-Duration Type 2 Diabetes Have Blunted Glycemic and [Beta]-Cell Function Improvements After Bariatric Surgery</title><author>Khanna, Vishesh ; Malin, Steven K ; Bena, James ; Abood, Beth ; Pothier, Claire E ; Bhatt, Deepak L ; Nissen, Steven ; Watanabe, Richard ; Brethauer, Stacy A ; Schauer, Philip R ; Kirwan, John P ; Kashyap, Sangeeta R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_16787226023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Glucose</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Obesity</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khanna, Vishesh</creatorcontrib><creatorcontrib>Malin, Steven K</creatorcontrib><creatorcontrib>Bena, James</creatorcontrib><creatorcontrib>Abood, Beth</creatorcontrib><creatorcontrib>Pothier, Claire E</creatorcontrib><creatorcontrib>Bhatt, Deepak L</creatorcontrib><creatorcontrib>Nissen, Steven</creatorcontrib><creatorcontrib>Watanabe, Richard</creatorcontrib><creatorcontrib>Brethauer, Stacy A</creatorcontrib><creatorcontrib>Schauer, Philip R</creatorcontrib><creatorcontrib>Kirwan, John P</creatorcontrib><creatorcontrib>Kashyap, Sangeeta R</creatorcontrib><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khanna, Vishesh</au><au>Malin, Steven K</au><au>Bena, James</au><au>Abood, Beth</au><au>Pothier, Claire E</au><au>Bhatt, Deepak L</au><au>Nissen, Steven</au><au>Watanabe, Richard</au><au>Brethauer, Stacy A</au><au>Schauer, Philip R</au><au>Kirwan, John P</au><au>Kashyap, Sangeeta R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adults with Long-Duration Type 2 Diabetes Have Blunted Glycemic and [Beta]-Cell Function Improvements After Bariatric Surgery</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><date>2015-03-01</date><risdate>2015</risdate><volume>23</volume><issue>3</issue><spage>523</spage><pages>523-</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery. Twenty-seven adults with short- (&lt;5 years) and long-duration (≥10 years) type 2 diabetes received a mixed-meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first- and second-phase meal-stimulated insulin secretion, disposition index (i.e., DI or pancreatic β-cell function), and incretin responses were examined. Adults with short-duration type 2 diabetes had better HbA^sub 1c^, greater insulin secretory capacity, and greater DI compared with adults with long-duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA^sub 1c^ and DI but not weight loss. Enhanced β-cell function characterizes the effect of bariatric surgery in adults with diabetes for &lt;5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long-standing type 2 diabetes.</abstract><cop>Silver Spring</cop><pub>Blackwell Publishing Ltd</pub></addata></record>
fulltext fulltext
identifier ISSN: 1930-7381
ispartof Obesity (Silver Spring, Md.), 2015-03, Vol.23 (3), p.523
issn 1930-7381
1930-739X
language eng
recordid cdi_proquest_journals_1678722602
source Wiley
subjects Glucose
Hyperglycemia
Insulin
Obesity
Rodents
title Adults with Long-Duration Type 2 Diabetes Have Blunted Glycemic and [Beta]-Cell Function Improvements After Bariatric Surgery
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T02%3A46%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adults%20with%20Long-Duration%20Type%202%20Diabetes%20Have%20Blunted%20Glycemic%20and%20%5BBeta%5D-Cell%20Function%20Improvements%20After%20Bariatric%20Surgery&rft.jtitle=Obesity%20(Silver%20Spring,%20Md.)&rft.au=Khanna,%20Vishesh&rft.date=2015-03-01&rft.volume=23&rft.issue=3&rft.spage=523&rft.pages=523-&rft.issn=1930-7381&rft.eissn=1930-739X&rft_id=info:doi/&rft_dat=%3Cproquest%3E3675207041%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_16787226023%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1678722602&rft_id=info:pmid/&rfr_iscdi=true