Osteocalcin, but not deoxypyridinoline, increases in response to isoflurane-induced anaesthesia in young female guinea pigs

The effect of the inhaled anaesthetic isoflurane was investigated on bone biomarkers, both during maturation and on minerals and glucose postpartum. Female guinea pigs ( n  = 10) were anaesthetized during maturation (5 and 9 weeks) and postpartum (26 weeks of age) with isoflurane during dual-energy...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2015-05, Vol.33 (3), p.253-260
Main Authors: Tabatabaei, Negar, Rodd, Celia J., Kremer, Richard, Weiler, Hope A.
Format: Article
Language:English
Subjects:
Amino Acids - therapeutic use
Anesthesia - methods
Animals
Anthropometry
Body Composition
Female
Guinea Pigs
Hydrocortisone - blood
Isoflurane - toxicity
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Orthopedics
Osteocalcin - therapeutic use
Pregnancy
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Summary:The effect of the inhaled anaesthetic isoflurane was investigated on bone biomarkers, both during maturation and on minerals and glucose postpartum. Female guinea pigs ( n  = 10) were anaesthetized during maturation (5 and 9 weeks) and postpartum (26 weeks of age) with isoflurane during dual-energy X-ray absorptiometry scanning. Blood collection was performed at all ages before and after anaesthesia for measurement of plasma osteocalcin (OC), total deoxypyridinoline (tDPD), and cortisol. Postpartum measurements also included: blood ions, acid–base parameters and glucose, plasma minerals, total alkaline phosphatase (tALP), and albumin. Plasma OC concentration almost doubled after exposure to isoflurane at 5 weeks (30.1 ± 5.0–57.9 ± 11.2 nmol/L, p  
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-014-0593-7