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Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011
Introduction This 10-year retrospective study analyzed the incidence of malignant transformation of oral lichen planus (OLP). The study also included dysplasia and oral lichenoid lesion (OLL) in the initial biopsy as a potential differential diagnosis. Material and methods A total of 692 scalpel bio...
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| Published in: | Oral and maxillofacial surgery 2015-06, Vol.19 (2), p.149-156 |
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| container_title | Oral and maxillofacial surgery |
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| creator | Casparis, S. Borm, J. M. Tektas, S. Kamarachev, J. Locher, M. C. Damerau, G. Grätz, K. W. Stadlinger, B. |
| description | Introduction
This 10-year retrospective study analyzed the incidence of malignant transformation of oral lichen planus (OLP). The study also included dysplasia and oral lichenoid lesion (OLL) in the initial biopsy as a potential differential diagnosis.
Material and methods
A total of 692 scalpel biopsies were taken from 542 patients (207 [38.2 %] men and 335 [61.8 %] women). Clinical and histopathological parameters were analyzed.
Results
The parameters gender (
p
= 0.022) and smoking behavior (
p
|
| doi_str_mv | 10.1007/s10006-014-0469-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1680917784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3684936051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-87b631ab8ad8ce22569a039efbd692aa1f4ad39fc5ef1408e49d434b1d8733aa3</originalsourceid><addsrcrecordid>eNp1kc1OHSEUx4nRqLU-QDeGxI1NHMuB-WDcNaatJje5XdQ1OQOMYuYOI8xtMjvfwa1P1ycpt6PWjRsg_D_g5EfIJ2BnwFj1JaaVlRmDPGN5WWfTFtkHWRYZFGW9_Xou2B75EONd8nIo2C7Z44VgUvBynzwtA3a0c_rW9nTosF9HerJc_Px8Sv1_xTtDOxud7_-pixfVTDFlosNTir2Z7zT22oZzGuwYfBysHt1vm2Tspugi9S3Vneud9gOOt77zN05vmnBE2ga_opwx_ufhkTOAj2SnxS7aw-f9gFx___br4jJbLH9cXXxdZLooYMxk1ZQCsJFopLacp-GRidq2jSlrjghtjkbUrS5sCzmTNq9NLvIGjKyEQBQH5HjuHYK_X9s4qju_DunHUUEpWQ1VJfPkgtml01wx2FYNwa0wTAqY2vBQMw-VeKgNDzWlzNFz87pZWfOaeAGQDHw2xCT1Nza8efrd1r_NzZcf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1680917784</pqid></control><display><type>article</type><title>Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011</title><source>Springer Nature</source><creator>Casparis, S. ; Borm, J. M. ; Tektas, S. ; Kamarachev, J. ; Locher, M. C. ; Damerau, G. ; Grätz, K. W. ; Stadlinger, B.</creator><creatorcontrib>Casparis, S. ; Borm, J. M. ; Tektas, S. ; Kamarachev, J. ; Locher, M. C. ; Damerau, G. ; Grätz, K. W. ; Stadlinger, B.</creatorcontrib><description>Introduction
This 10-year retrospective study analyzed the incidence of malignant transformation of oral lichen planus (OLP). The study also included dysplasia and oral lichenoid lesion (OLL) in the initial biopsy as a potential differential diagnosis.
Material and methods
A total of 692 scalpel biopsies were taken from 542 patients (207 [38.2 %] men and 335 [61.8 %] women). Clinical and histopathological parameters were analyzed.
Results
The parameters gender (
p
= 0.022) and smoking behavior (
p
< 0.001) were significantly associated with the severity of diagnosis. Mucosal lesions with an ulcerative appearance (
p
= 0.006) and those located on the floor of the mouth (
p
< 0.001) showed significantly higher degrees of dysplasia or were diagnosed as oral squamous cell carcinoma (OSCC). Smoking and joint disease appeared to be significant risk factors. Treatment with tretinoin in different concentrations (0.005–0.02 %) significantly improved diagnosis. Twelve patients (8 female, 4 male) showed malignant transformation to OSCC within an average period of 1.58 years. The malignant transformation rate (MTR) was higher for OLL (4.4 %) than OLP (1.2 %). If the first biopsy showed intraepithelial neoplasia, the risk of developing OSCC increased (by 3.5 % for squamous intraepithelial neoplasia (SIN) II and by 6.7 % for SIN III).
Conclusion
Although we cannot rule out that OLP is a premalignant oral condition, we can confirm that OLP had the lowest MTR of all diagnoses.</description><identifier>ISSN: 1865-1550</identifier><identifier>EISSN: 1865-1569</identifier><identifier>DOI: 10.1007/s10006-014-0469-y</identifier><identifier>PMID: 25308326</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Cell Transformation, Neoplastic - pathology ; Diagnosis, Differential ; Female ; Humans ; Lichen Planus, Oral - diagnosis ; Lichen Planus, Oral - pathology ; Lichenoid Eruptions - diagnosis ; Lichenoid Eruptions - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mouth Diseases - diagnosis ; Mouth Diseases - pathology ; Mouth Mucosa - pathology ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - pathology ; Oral and Maxillofacial Surgery ; Original Article ; Precancerous Conditions - diagnosis ; Precancerous Conditions - pathology ; Retrospective Studies ; Young Adult</subject><ispartof>Oral and maxillofacial surgery, 2015-06, Vol.19 (2), p.149-156</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-87b631ab8ad8ce22569a039efbd692aa1f4ad39fc5ef1408e49d434b1d8733aa3</citedby><cites>FETCH-LOGICAL-c551t-87b631ab8ad8ce22569a039efbd692aa1f4ad39fc5ef1408e49d434b1d8733aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25308326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Casparis, S.</creatorcontrib><creatorcontrib>Borm, J. M.</creatorcontrib><creatorcontrib>Tektas, S.</creatorcontrib><creatorcontrib>Kamarachev, J.</creatorcontrib><creatorcontrib>Locher, M. C.</creatorcontrib><creatorcontrib>Damerau, G.</creatorcontrib><creatorcontrib>Grätz, K. W.</creatorcontrib><creatorcontrib>Stadlinger, B.</creatorcontrib><title>Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011</title><title>Oral and maxillofacial surgery</title><addtitle>Oral Maxillofac Surg</addtitle><addtitle>Oral Maxillofac Surg</addtitle><description>Introduction
This 10-year retrospective study analyzed the incidence of malignant transformation of oral lichen planus (OLP). The study also included dysplasia and oral lichenoid lesion (OLL) in the initial biopsy as a potential differential diagnosis.
Material and methods
A total of 692 scalpel biopsies were taken from 542 patients (207 [38.2 %] men and 335 [61.8 %] women). Clinical and histopathological parameters were analyzed.
Results
The parameters gender (
p
= 0.022) and smoking behavior (
p
< 0.001) were significantly associated with the severity of diagnosis. Mucosal lesions with an ulcerative appearance (
p
= 0.006) and those located on the floor of the mouth (
p
< 0.001) showed significantly higher degrees of dysplasia or were diagnosed as oral squamous cell carcinoma (OSCC). Smoking and joint disease appeared to be significant risk factors. Treatment with tretinoin in different concentrations (0.005–0.02 %) significantly improved diagnosis. Twelve patients (8 female, 4 male) showed malignant transformation to OSCC within an average period of 1.58 years. The malignant transformation rate (MTR) was higher for OLL (4.4 %) than OLP (1.2 %). If the first biopsy showed intraepithelial neoplasia, the risk of developing OSCC increased (by 3.5 % for squamous intraepithelial neoplasia (SIN) II and by 6.7 % for SIN III).
Conclusion
Although we cannot rule out that OLP is a premalignant oral condition, we can confirm that OLP had the lowest MTR of all diagnoses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Lichen Planus, Oral - diagnosis</subject><subject>Lichen Planus, Oral - pathology</subject><subject>Lichenoid Eruptions - diagnosis</subject><subject>Lichenoid Eruptions - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mouth Diseases - diagnosis</subject><subject>Mouth Diseases - pathology</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Original Article</subject><subject>Precancerous Conditions - diagnosis</subject><subject>Precancerous Conditions - pathology</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>1865-1550</issn><issn>1865-1569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kc1OHSEUx4nRqLU-QDeGxI1NHMuB-WDcNaatJje5XdQ1OQOMYuYOI8xtMjvfwa1P1ycpt6PWjRsg_D_g5EfIJ2BnwFj1JaaVlRmDPGN5WWfTFtkHWRYZFGW9_Xou2B75EONd8nIo2C7Z44VgUvBynzwtA3a0c_rW9nTosF9HerJc_Px8Sv1_xTtDOxud7_-pixfVTDFlosNTir2Z7zT22oZzGuwYfBysHt1vm2Tspugi9S3Vneud9gOOt77zN05vmnBE2ga_opwx_ufhkTOAj2SnxS7aw-f9gFx___br4jJbLH9cXXxdZLooYMxk1ZQCsJFopLacp-GRidq2jSlrjghtjkbUrS5sCzmTNq9NLvIGjKyEQBQH5HjuHYK_X9s4qju_DunHUUEpWQ1VJfPkgtml01wx2FYNwa0wTAqY2vBQMw-VeKgNDzWlzNFz87pZWfOaeAGQDHw2xCT1Nza8efrd1r_NzZcf</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Casparis, S.</creator><creator>Borm, J. M.</creator><creator>Tektas, S.</creator><creator>Kamarachev, J.</creator><creator>Locher, M. C.</creator><creator>Damerau, G.</creator><creator>Grätz, K. W.</creator><creator>Stadlinger, B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150601</creationdate><title>Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011</title><author>Casparis, S. ; Borm, J. M. ; Tektas, S. ; Kamarachev, J. ; Locher, M. C. ; Damerau, G. ; Grätz, K. W. ; Stadlinger, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-87b631ab8ad8ce22569a039efbd692aa1f4ad39fc5ef1408e49d434b1d8733aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Lichen Planus, Oral - diagnosis</topic><topic>Lichen Planus, Oral - pathology</topic><topic>Lichenoid Eruptions - diagnosis</topic><topic>Lichenoid Eruptions - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mouth Diseases - diagnosis</topic><topic>Mouth Diseases - pathology</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Original Article</topic><topic>Precancerous Conditions - diagnosis</topic><topic>Precancerous Conditions - pathology</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Casparis, S.</creatorcontrib><creatorcontrib>Borm, J. M.</creatorcontrib><creatorcontrib>Tektas, S.</creatorcontrib><creatorcontrib>Kamarachev, J.</creatorcontrib><creatorcontrib>Locher, M. C.</creatorcontrib><creatorcontrib>Damerau, G.</creatorcontrib><creatorcontrib>Grätz, K. W.</creatorcontrib><creatorcontrib>Stadlinger, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Casparis, S.</au><au>Borm, J. M.</au><au>Tektas, S.</au><au>Kamarachev, J.</au><au>Locher, M. C.</au><au>Damerau, G.</au><au>Grätz, K. W.</au><au>Stadlinger, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011</atitle><jtitle>Oral and maxillofacial surgery</jtitle><stitle>Oral Maxillofac Surg</stitle><addtitle>Oral Maxillofac Surg</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>19</volume><issue>2</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>1865-1550</issn><eissn>1865-1569</eissn><abstract>Introduction
This 10-year retrospective study analyzed the incidence of malignant transformation of oral lichen planus (OLP). The study also included dysplasia and oral lichenoid lesion (OLL) in the initial biopsy as a potential differential diagnosis.
Material and methods
A total of 692 scalpel biopsies were taken from 542 patients (207 [38.2 %] men and 335 [61.8 %] women). Clinical and histopathological parameters were analyzed.
Results
The parameters gender (
p
= 0.022) and smoking behavior (
p
< 0.001) were significantly associated with the severity of diagnosis. Mucosal lesions with an ulcerative appearance (
p
= 0.006) and those located on the floor of the mouth (
p
< 0.001) showed significantly higher degrees of dysplasia or were diagnosed as oral squamous cell carcinoma (OSCC). Smoking and joint disease appeared to be significant risk factors. Treatment with tretinoin in different concentrations (0.005–0.02 %) significantly improved diagnosis. Twelve patients (8 female, 4 male) showed malignant transformation to OSCC within an average period of 1.58 years. The malignant transformation rate (MTR) was higher for OLL (4.4 %) than OLP (1.2 %). If the first biopsy showed intraepithelial neoplasia, the risk of developing OSCC increased (by 3.5 % for squamous intraepithelial neoplasia (SIN) II and by 6.7 % for SIN III).
Conclusion
Although we cannot rule out that OLP is a premalignant oral condition, we can confirm that OLP had the lowest MTR of all diagnoses.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25308326</pmid><doi>10.1007/s10006-014-0469-y</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Springer Nature |
| subjects | Adolescent Adult Aged Aged, 80 and over Biopsy Cell Transformation, Neoplastic - pathology Diagnosis, Differential Female Humans Lichen Planus, Oral - diagnosis Lichen Planus, Oral - pathology Lichenoid Eruptions - diagnosis Lichenoid Eruptions - pathology Male Medicine Medicine & Public Health Middle Aged Mouth Diseases - diagnosis Mouth Diseases - pathology Mouth Mucosa - pathology Mouth Neoplasms - diagnosis Mouth Neoplasms - pathology Oral and Maxillofacial Surgery Original Article Precancerous Conditions - diagnosis Precancerous Conditions - pathology Retrospective Studies Young Adult |
| title | Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002–2011 |
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