effects of season and gender on the serum aflatoxins and ochratoxin A levels of healthy adult subjects from the Central Anatolia Region, Turkey

PURPOSE: This study was undertaken to determine the effects of season and gender on serum aflatoxin (AF) levels (AFG₁, AFB₁, AFG₂ and AFB₂) and ochratoxin A (OTA) concentrations of healthy adult population living in Central Anatolia Region of Turkey. METHODS: AF levels were measured by high-performa...

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Bibliographic Details
Published in:European journal of nutrition 2015-06, Vol.54 (4), p.629-638
Main Authors: Sabuncuoglu, Suna, Erkekoglu, Pinar, Aydin, Sevtap, Şahin, Gönül, Kocer-Gumusel, Belma
Format: Article
Language:English
Subjects:
Adolescent
Adult
adults
aflatoxin B1
aflatoxin B2
aflatoxin G1
Aflatoxins - blood
blood serum
Chemistry
Chemistry and Materials Science
Chromatography, High Pressure Liquid
Enzyme-Linked Immunosorbent Assay
Fasting
Female
females
Food Contamination - analysis
Food Microbiology
high performance liquid chromatography
Humans
Male
males
Middle Aged
Nutrition
ochratoxin A
Ochratoxins - blood
Original Contribution
seasonal variation
Seasons
Sex Factors
summer
Turkey
winter
Young Adult
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Summary:PURPOSE: This study was undertaken to determine the effects of season and gender on serum aflatoxin (AF) levels (AFG₁, AFB₁, AFG₂ and AFB₂) and ochratoxin A (OTA) concentrations of healthy adult population living in Central Anatolia Region of Turkey. METHODS: AF levels were measured by high-performance liquid chromatography (HPLC) and OTA levels were measured by enzyme-linked immunosorbent assay (ELISA) in serum samples of healthy adults (n = 233). RESULTS: In summer and winter, total AF levels in females were 0.98 ± 0.10 and 0.94 ± 0.12 ng/ml and in males 1.35 ± 0.17 and 0.93 ± 0.11 ng/ml, respectively. Male subjects had significantly higher serum total AF levels in summer compared with females (~38 %). There was no marked seasonal change in AFG₁, AFB₁ and AFG₂ concentrations in the whole population, except AFB₂. Both of the genders had significantly higher OTA levels in winter compared with summer (~60 %). CONCLUSIONS: Overall results suggest that Central Anatolia residents are continuously exposed to AFs and OTA. Besides, season and gender can be effective in mycotoxin exposure.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-014-0744-6