Potential therapeutic Mn2+ and Ni2+ complexes of new 4-acetyl-3-methyl-1-phenyl-2-pyrazoline-5-one phenylhydrazone Ampp-Ph

Summary Schiff base of acetylpyrazolone phenylhydrazone Ampp‐Ph was synthesized from the reaction of synthesized acetylpyrazolone diketone precursor Ampp with phenylhydrazine. On reacting the isolated Schiff base in ethanol with aqueous solution of manganese or nickel chloride salts afforded the met...

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Bibliographic Details
Published in:Macromolecular symposia. 2015-05, Vol.351 (1), p.61-68
Main Authors: Idemudia, Omoruyi G., Sadimenko, Alexander P., Afolayan, Anthony J.
Format: Article
Language:English
Subjects:
acylpyrazolone
antibacterial screening
Aqueous solutions
Free radicals
Metals
phenylhydrazine
Schiff bases
transition metal complexes
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Summary:Summary Schiff base of acetylpyrazolone phenylhydrazone Ampp‐Ph was synthesized from the reaction of synthesized acetylpyrazolone diketone precursor Ampp with phenylhydrazine. On reacting the isolated Schiff base in ethanol with aqueous solution of manganese or nickel chloride salts afforded the metal complexes of acetylpyrazolone phenylhydrazone. Based on elemental, analytical and spectroscopic studies a bidentate keto tautomer Schiff base forming an octahedral complex with the metal ion has been proposed. Varying antibacterial activities against selected bacterial isolates have been observed using the paper disc diffusion method at 40mg/ml. A significant free radical scavenging (antioxidant) capability against DPPH was exhibited by the synthesized compounds.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.201300128