Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility...

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Published in:Environmental geochemistry and health 2015-06, Vol.37 (3), p.515-527
Main Authors: Zafar, Ambreen, Eqani, Syed Ali Musstjab Akber Shah, Bostan, Nazish, Cincinelli, Alessandra, Tahir, Faheem, Shah, Syed Tahir Abbas, Hussain, Alamdar, Alamdar, Ambreen, Huang, Qingyu, Peng, Siyuan, Shen, Heqing
Format: Article
Language:English
Subjects:
Cadmium
Cadmium - analysis
chromium
cooking fats and oils
Cooking oils
copper
correlation
Earth and Environmental Science
Environment
Environmental Chemistry
Environmental Health
flour
Geochemistry
ghee
guidelines
Humans
Infertility
Infertility, Male - epidemiology
lead
Male
male fertility
males
Mass spectrometry
mercury
Metal concentrations
Metals
Metals, Heavy - analysis
nickel
Nickel - analysis
Original Paper
Pakistan - epidemiology
Plasma
Public Health
Semen - chemistry
Semen Analysis
seminal plasma
Soil Science & Conservation
Sperm
sperm concentration
Terrestrial Pollution
tin
Toxicity
Trace Elements - analysis
Trace metals
World Health Organization
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creator Zafar, Ambreen
Eqani, Syed Ali Musstjab Akber Shah
Bostan, Nazish
Cincinelli, Alessandra
Tahir, Faheem
Shah, Syed Tahir Abbas
Hussain, Alamdar
Alamdar, Ambreen
Huang, Qingyu
Peng, Siyuan
Shen, Heqing
description Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p 
doi_str_mv 10.1007/s10653-014-9666-8
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Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p &lt; 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = −0.26, −0.29) and motility (r = −0.33, −0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.</description><identifier>ISSN: 0269-4042</identifier><identifier>EISSN: 1573-2983</identifier><identifier>DOI: 10.1007/s10653-014-9666-8</identifier><identifier>PMID: 25471479</identifier><language>eng</language><publisher>Dordrecht: Springer-Verlag</publisher><subject>Cadmium ; Cadmium - analysis ; chromium ; cooking fats and oils ; Cooking oils ; copper ; correlation ; Earth and Environmental Science ; Environment ; Environmental Chemistry ; Environmental Health ; flour ; Geochemistry ; ghee ; guidelines ; Humans ; Infertility ; Infertility, Male - epidemiology ; lead ; Male ; male fertility ; males ; Mass spectrometry ; mercury ; Metal concentrations ; Metals ; Metals, Heavy - analysis ; nickel ; Nickel - analysis ; Original Paper ; Pakistan - epidemiology ; Plasma ; Public Health ; Semen - chemistry ; Semen Analysis ; seminal plasma ; Soil Science &amp; Conservation ; Sperm ; sperm concentration ; Terrestrial Pollution ; tin ; Toxicity ; Trace Elements - analysis ; Trace metals ; World Health Organization</subject><ispartof>Environmental geochemistry and health, 2015-06, Vol.37 (3), p.515-527</ispartof><rights>Springer Science+Business Media Dordrecht 2014</rights><rights>Springer Science+Business Media Dordrecht 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-e0ed21d2d7c8844e4857c7d182e8bded522799ab23c0ca1317ae66dc84973ab83</citedby><cites>FETCH-LOGICAL-c466t-e0ed21d2d7c8844e4857c7d182e8bded522799ab23c0ca1317ae66dc84973ab83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25471479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zafar, Ambreen</creatorcontrib><creatorcontrib>Eqani, Syed Ali Musstjab Akber Shah</creatorcontrib><creatorcontrib>Bostan, Nazish</creatorcontrib><creatorcontrib>Cincinelli, Alessandra</creatorcontrib><creatorcontrib>Tahir, Faheem</creatorcontrib><creatorcontrib>Shah, Syed Tahir Abbas</creatorcontrib><creatorcontrib>Hussain, Alamdar</creatorcontrib><creatorcontrib>Alamdar, Ambreen</creatorcontrib><creatorcontrib>Huang, Qingyu</creatorcontrib><creatorcontrib>Peng, Siyuan</creatorcontrib><creatorcontrib>Shen, Heqing</creatorcontrib><title>Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility</title><title>Environmental geochemistry and health</title><addtitle>Environ Geochem Health</addtitle><addtitle>Environ Geochem Health</addtitle><description>Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p &lt; 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = −0.26, −0.29) and motility (r = −0.33, −0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.</description><subject>Cadmium</subject><subject>Cadmium - analysis</subject><subject>chromium</subject><subject>cooking fats and oils</subject><subject>Cooking oils</subject><subject>copper</subject><subject>correlation</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>flour</subject><subject>Geochemistry</subject><subject>ghee</subject><subject>guidelines</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility, Male - epidemiology</subject><subject>lead</subject><subject>Male</subject><subject>male fertility</subject><subject>males</subject><subject>Mass spectrometry</subject><subject>mercury</subject><subject>Metal concentrations</subject><subject>Metals</subject><subject>Metals, Heavy - analysis</subject><subject>nickel</subject><subject>Nickel - analysis</subject><subject>Original Paper</subject><subject>Pakistan - epidemiology</subject><subject>Plasma</subject><subject>Public Health</subject><subject>Semen - chemistry</subject><subject>Semen Analysis</subject><subject>seminal plasma</subject><subject>Soil Science &amp; Conservation</subject><subject>Sperm</subject><subject>sperm concentration</subject><subject>Terrestrial Pollution</subject><subject>tin</subject><subject>Toxicity</subject><subject>Trace Elements - analysis</subject><subject>Trace metals</subject><subject>World Health Organization</subject><issn>0269-4042</issn><issn>1573-2983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kEtv1TAQRi0EoreFH8AGLLEOjB_xY4mq8pAqgUS7tuYmzq1LYgfbUem_J7cpiBWrkezvO6M5hLxi8I4B6PeFgWpFA0w2VinVmCdkx1otGm6NeEp2wJVtJEh-Qk5LuQUAq6V5Tk54KzWT2u7I3VX6FTo6-YpjoSUcItYlexoirTee3iwTRlr8FCKOdB6xTEjTQL_hj1AqxkDnNC8j1pAixdgfSyGvj9XHGtZKTuMDbMKHOfhcwxjq_QvybFg3-peP84xcf7y4Ov_cXH799OX8w2XTSaVq48H3nPW8150xUnppWt3pnhnuzb73fcu5thb3XHTQIRNMo1eq74y0WuDeiDPyduPOOf1cfKnuNi15PaY4powQEpSENcW2VJdTKdkPbs5hwnzvGLijarepdqtqd1TtjuTXj-RlP_n-b-OP2zXAt0BZv-LB539W_4f6ZisNmBweciju-jsH1gIwyy1T4jfFVpRQ</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Zafar, Ambreen</creator><creator>Eqani, Syed Ali Musstjab Akber Shah</creator><creator>Bostan, Nazish</creator><creator>Cincinelli, Alessandra</creator><creator>Tahir, Faheem</creator><creator>Shah, Syed Tahir Abbas</creator><creator>Hussain, Alamdar</creator><creator>Alamdar, Ambreen</creator><creator>Huang, Qingyu</creator><creator>Peng, Siyuan</creator><creator>Shen, Heqing</creator><general>Springer-Verlag</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope></search><sort><creationdate>20150601</creationdate><title>Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility</title><author>Zafar, Ambreen ; 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source Springer Nature
subjects Cadmium
Cadmium - analysis
chromium
cooking fats and oils
Cooking oils
copper
correlation
Earth and Environmental Science
Environment
Environmental Chemistry
Environmental Health
flour
Geochemistry
ghee
guidelines
Humans
Infertility
Infertility, Male - epidemiology
lead
Male
male fertility
males
Mass spectrometry
mercury
Metal concentrations
Metals
Metals, Heavy - analysis
nickel
Nickel - analysis
Original Paper
Pakistan - epidemiology
Plasma
Public Health
Semen - chemistry
Semen Analysis
seminal plasma
Soil Science & Conservation
Sperm
sperm concentration
Terrestrial Pollution
tin
Toxicity
Trace Elements - analysis
Trace metals
World Health Organization
title Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility
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