The significance of cadherin for cell-cell interactions and cell adhesions on biomaterials

Cadherins are surface glycoproteins on plasma membranes and exist in many forms: T-cadherin, neuronal cadherin (N-cadherin), epithelial cadherin (E-cadherin), and vascular endothelial (VE-cadherin). Cadherins play critical roles in cell-cell interactions and are involved in multiple functions relate...

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Bibliographic Details
Published in:Journal of adhesion science and technology 2015-06, Vol.29 (11), p.1047-1059
Main Authors: Hu, Xingyou, Shen, Gaotian, Hu, Tao, Guan, Guoping, Wang, Lu
Format: Article
Language:English
Subjects:
cadherin
Cell adhesion & migration
Cell growth
cell-cell reaction
endothelial cells
Morphology
surface morphology
vascular vessels
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Summary:Cadherins are surface glycoproteins on plasma membranes and exist in many forms: T-cadherin, neuronal cadherin (N-cadherin), epithelial cadherin (E-cadherin), and vascular endothelial (VE-cadherin). Cadherins play critical roles in cell-cell interactions and are involved in multiple functions related to cell growth and proliferation. Findings from numerous reports have indicated that VE-cadherin regulates the remodeling, gating, and maturation of vascular vessels. The surface morphology of materials also impacts endothelial cell adhesion. This report is an overview of recent research on the effects of cadherins on cell-cell interactions, along with cell adhesions as examined on different materials. This summary will provide novel insights and approaches for research on cell-cell and cell-material interactions and illuminate some of the mechanisms of cell growth on different materials.
ISSN:0169-4243
1568-5616
DOI:10.1080/01694243.2015.1018731