Recombinant Antigens Expressed in Pichia pastoris for the Diagnosis of Sleeping Sickness Caused by Trypanosoma brucei gambiense: e3006

[...]these strains typically exhibit slower growth rates, lower transformation efficiencies and lower viabilities. [...]they are not available in the GlycoSwitch format [46]. [...]the SUMO fragment could also be removed from the fusion proteins with SUMO protease 2 but neither the sensitivity nor th...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2014-07, Vol.8 (7)
Main Authors: Rogé, Stijn, Nieuwenhove, Liesbeth Van, Meul, Magali, Heykers, Annick, Koning, Annette Brouwerde, Bebronne, Nicolas, Guisez, Yves, Büscher, Philippe
Format: Article
Language:English
Subjects:
Infections
Laboratory animals
Parasites
Proteins
Tropical diseases
Vector-borne diseases
Online Access:Get full text
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Description
Summary:[...]these strains typically exhibit slower growth rates, lower transformation efficiencies and lower viabilities. [...]they are not available in the GlycoSwitch format [46]. [...]the SUMO fragment could also be removed from the fusion proteins with SUMO protease 2 but neither the sensitivity nor the specificity of the recombinants seem to be impaired by the presence of the SUMO protein.
ISSN:1935-2727
1935-2735
DOI:10.1371/journal.pntd.0003006