Wolbachia Enhances West Nile Virus (WNV) Infection in the Mosquito Culex tarsalis: e2965

Quantitative PCR of selected innate immune genes indicated that REL1 (the activator of the antiviral Toll immune pathway) was down regulated in Wolbachia-infected relative to control mosquitoes. [...]Wolbachia increases Plasmodium berghei, P. yoelii and P. gallinaceum oocyst loads in Anopheles gambi...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2014-07, Vol.8 (7)
Main Authors: Dodson, Brittany L, Hughes, Grant L, Paul, Oluwatobi, Matacchiero, Amy C, Kramer, Laura D, Rasgon, Jason L
Format: Article
Language:English
Subjects:
Aquatic insects
Bacteria
Disease control
Drug resistance
Experiments
Gene expression
Infections
Insects
Methods
Microscopy
Mortality
Mosquitoes
Studies
Tropical diseases
Urban agriculture
Urban areas
Vector-borne diseases
Viruses
West Nile virus
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Summary:Quantitative PCR of selected innate immune genes indicated that REL1 (the activator of the antiviral Toll immune pathway) was down regulated in Wolbachia-infected relative to control mosquitoes. [...]Wolbachia increases Plasmodium berghei, P. yoelii and P. gallinaceum oocyst loads in Anopheles gambiae, An. stephensi, and Aedes fluviatilis, respectively [17]-[19], and P. relictum sporozoite prevalence in Culex pipiens [20]. Culex tarsalis is a mosquito species associated with agriculture and urban areas in the western United States [23] and is highly competent for West Nile virus (WNV), St. Louis encephalitis virus (SLEV) and western equine encephalitis virus (WEEV) [24]-[26].
ISSN:1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002965