The Antiinflammatory Properties of Humic Substances: A Mini Review

Humic substances are effective in the suppression of delayed type hypersensitivity, rat paw oedema, a graft‐versus‐host reaction and contact hypersensitivity in rats. They reduce the C‐reactive protein levels of patients suffering from osteoarthritis of the knee and the wheel and flare reaction of p...

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Bibliographic Details
Published in:Phytotherapy research 2015-06, Vol.29 (6), p.791-795
Main Author: van Rensburg, Constance E. J.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Benzopyrans - pharmacology
C-Reactive Protein - chemistry
Clinical Trials as Topic
Dermatitis, Contact - drug therapy
Drug Evaluation, Preclinical
Edema - drug therapy
fulvic acid
Graft vs Host Disease - prevention & control
Humans
humic acid
Humic Substances
Hypersensitivity, Delayed - drug therapy
inflammation
Osteoarthritis, Knee - drug therapy
potassium humate
Rats
Soil - chemistry
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Summary:Humic substances are effective in the suppression of delayed type hypersensitivity, rat paw oedema, a graft‐versus‐host reaction and contact hypersensitivity in rats. They reduce the C‐reactive protein levels of patients suffering from osteoarthritis of the knee and the wheel and flare reaction of patients suffering from hay fever. They have also been described as cardioprotective and pro‐angiogenic. Toxicity studies have indicated that potassium humate is safe in humans up to a daily dosage of 1 g/kg, whereas fulvic acid is safe in humans up to a daily dosage of 1.8 g per adult. The antiinflammatory action of potassium humate can be contributed to the inhibition of the release of inflammatory‐related cytokines, an adhesion molecule, oxidants and components of the complement system. Copyright © 2015 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.5319