Simulation of the fibroblast effect on electrical activity of sinoatrial node cells

It was found via the mathematical simulation of the effect of fibroblasts on the electrical activity of the sinoatrial node cells that the interaction with fibroblasts through gap junctions increases the oscillation frequency of pacemakers. Under the effect of fibroblasts, the oscillation amplitude...

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Bibliographic Details
Published in:Biophysics (Oxford) 2015-03, Vol.60 (2), p.256-262
Main Authors: Tolstokorov, A. S., Syunyaev, R. A., Aliev, R. R.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Cell Biophysics
Cells
Electric currents
Oscillators
Physics
Physics and Astronomy
Simulation
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Summary:It was found via the mathematical simulation of the effect of fibroblasts on the electrical activity of the sinoatrial node cells that the interaction with fibroblasts through gap junctions increases the oscillation frequency of pacemakers. Under the effect of fibroblasts, the oscillation amplitude of a true pacemaker decreases until the end of the spontaneous activity. The oscillation amplitude of a latent pacemaker decreases considerably less.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350915020190