Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

The glucose-responsive amphiphilic poly(PEGMA- co -AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator funct...

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Bibliographic Details
Published in:Colloid and polymer science 2015-07, Vol.293 (7), p.2129-2135
Main Authors: Du, Xiangxiang, Jiang, Guohua, Li, Lei, Liu, Yongkun, Chen, Hua, Huang, Qin
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Food Science
Nanotechnology and Microengineering
Physical Chemistry
Polymer Sciences
Short Communication
Soft and Granular Matter
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Summary:The glucose-responsive amphiphilic poly(PEGMA- co -AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by gas chromatography-mass spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA- co -AAPBA) micelles were characterized by 1 H NMR and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photopolymerization process. The as-prepared polymeric micelles exhibited the excellent glucose sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy of diabetes based on glucose-sensitive controlled drug delivery systems.
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-015-3625-5