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Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis

INTRODUCTION : We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis. METHODS : This cross-sectional study involved 79 patients infecte...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2015-05, Vol.48 (3), p.350
Main Authors: Paula, Carolina Valença Silva, Adriana, Vieira Gomes, Georgea, Gertrudes despaceOliveira Mendes, Maria, Rosângela Cunha Duarte, Maria, Tereza Cartaxo Muniz, Ana, Lúcia Coutinho Domingues
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Language:English
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Summary:INTRODUCTION : We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis. METHODS : This cross-sectional study involved 79 patients infected with Schistosoma mansoni with severe or mild/moderate periportal fibrosis. Serum concentrations of mannose-binding lectin were obtained by enzyme-linked immunosorbent assay (ELISA). RESULTS: Higher serum level of mannose-binding lectin was significantly associated with advanced periportal fibrosis. CONCLUSIONS: Mannose-binding lectin may contribute to liver pathology in schistosomiasis and may represent a risk factor for advanced periportal fibrosis in the Brazilian population studied.
ISSN:0037-8682
1678-9849
DOI:10.1590/0037-8682-0309-201