Prognostic value of high c-Met expression in patients with poor prognosis pancreatic adenocarcinoma (PAC) following surgical resection: comparison of three c-Met scoring methods and exploration of underlying mechanisms of c-Met overexpression

Hypoxia: HIF-1[alpha]/CA9 immunostaining, necrosis and CD31 staining. c-Met gene copy number: fluorescent in situ hybridization (FISH) and Taqman® based copy number variation (CNV) assay. c-Met mRNA levels: reverse transcription PCR (RT-PCR). c-Met pathway activation: phospho-c-Met, phospho-GAB1, ph...

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Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015-06, Vol.15 (3), p.S25-S26
Main Authors: Neuzillet, Cindy, Tijeras-Raballand, Annemilaï, Raffenne, Jérôme, Gramont, Armand D.E, Bedossa, Pierre, Paradis, Valérie, Sauvanet, Alain, Bachet, Jean-Baptiste, Raymond, Eric, Hammel, Pascal, Couvelard, Anne, Cros, Jérôme
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
Gastroenterology and Hepatology
Gene amplification
Hypoxia
Multivariate analysis
Online Access:Get full text
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Summary:Hypoxia: HIF-1[alpha]/CA9 immunostaining, necrosis and CD31 staining. c-Met gene copy number: fluorescent in situ hybridization (FISH) and Taqman® based copy number variation (CNV) assay. c-Met mRNA levels: reverse transcription PCR (RT-PCR). c-Met pathway activation: phospho-c-Met, phospho-GAB1, phospho-AKT, phospho-ERK, and phospho-STAT3 immunostaining.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.05.121