Decreased pS6 expression under MEK inhibitor (MEKi) correlates with response to MEKi alone or combined with PI3Ki-mTOR inhibitor (PI3Ki-mTORi) in pancreatic adenocarcinoma (PAC) in vitro and ex vivo models

Two tumor specimens were cultured ex vivo: (a) GSK1120212 (0.1 [micro]M) alone induced apoptosis concomitantly with pS6 decrease; (b) everolimus (1[micro]M) or BKM120 (0.1[micro]M) alone exerted antiproliferative but no cytotoxic effects; (c) combinations resulted in higher caspase 3 levels and decr...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015-06, Vol.15 (3), p.S25-S25
Main Authors: Neuzillet, Cindy, Tijeras-Raballand, Annemilaï, Cros, Jérôme, Bourgoin, Pierre, Bourget, Philippe, Serova, Maria, Gramont, Armand D.E, Faivre, Sandrine, Raymond, Eric, Ruszniewski, Philippe, Hammel, Pascal
Format: Article
Language:English
Subjects:
Apoptosis
Endocrinology & Metabolism
Gastroenterology and Hepatology
Mutation
Online Access:Get full text
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Summary:Two tumor specimens were cultured ex vivo: (a) GSK1120212 (0.1 [micro]M) alone induced apoptosis concomitantly with pS6 decrease; (b) everolimus (1[micro]M) or BKM120 (0.1[micro]M) alone exerted antiproliferative but no cytotoxic effects; (c) combinations resulted in higher caspase 3 levels and decrease pS6 than MEKi alone.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.05.119