Carboxylesterase 1 C.428G>A single nucleotide variation reduces hydrolysis of clopidogrel and enalapril, but not that of Quinapril

Conclusions The CES1 c.428G>A SNV increased clopidogrel active metabolite concentrations and antiplatelet effects by reducing hydrolysis of parent clopidogrel to inactive metabolites. [...]the CES1 c.428A allele may increase clopidogrel efficacy and bleeding risk.

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Bibliographic Details
Published in:Clinical therapeutics 2015-08, Vol.37 (8), p.e3-e3
Main Authors: Tarkiainen, E.K, Holmberg, M.T, Tornio, A, Neuvonen, M, Launiainen, T, Neuvonen, P.J, Backman, J.T, Niemi, M
Format: Article
Language:English
Subjects:
Internal Medicine
Medical Education
Metabolites
Online Access:Get full text
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Description
Summary:Conclusions The CES1 c.428G>A SNV increased clopidogrel active metabolite concentrations and antiplatelet effects by reducing hydrolysis of parent clopidogrel to inactive metabolites. [...]the CES1 c.428A allele may increase clopidogrel efficacy and bleeding risk.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.018