Valproic Acid and Carbapenems interaction: clinical outcomes

In three patients (33.3%) the drug interaction had clinical consequences (in one patient the VPA level dropped 40 mg/L causing a seizure, and in the other two their EEGs showed seizure activity without clinical convulsions, probably due to general sedation).

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Bibliographic Details
Published in:Clinical therapeutics 2015-08, Vol.37 (8), p.e113-e113
Main Authors: Arellano, A.L, Barriocanal, A, Sanz, Y, Montané, E
Format: Article
Language:English
Subjects:
Convulsions & seizures
Electroencephalography
Internal Medicine
Medical Education
Patients
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Description
Summary:In three patients (33.3%) the drug interaction had clinical consequences (in one patient the VPA level dropped 40 mg/L causing a seizure, and in the other two their EEGs showed seizure activity without clinical convulsions, probably due to general sedation).
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.323