Valproic Acid and Carbapenems interaction: clinical outcomes

In three patients (33.3%) the drug interaction had clinical consequences (in one patient the VPA level dropped 40 mg/L causing a seizure, and in the other two their EEGs showed seizure activity without clinical convulsions, probably due to general sedation).

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Published in:Clinical therapeutics 2015-08, Vol.37 (8), p.e113-e113
Main Authors: Arellano, A.L, Barriocanal, A, Sanz, Y, Montané, E
Format: Article
Language:English
Subjects:
Convulsions & seizures
Electroencephalography
Internal Medicine
Medical Education
Patients
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container_end_page e113
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container_title Clinical therapeutics
container_volume 37
creator Arellano, A.L
Barriocanal, A
Sanz, Y
Montané, E
description In three patients (33.3%) the drug interaction had clinical consequences (in one patient the VPA level dropped 40 mg/L causing a seizure, and in the other two their EEGs showed seizure activity without clinical convulsions, probably due to general sedation).
doi_str_mv 10.1016/j.clinthera.2015.05.323
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source ScienceDirect Freedom Collection
subjects Convulsions & seizures
Electroencephalography
Internal Medicine
Medical Education
Patients
title Valproic Acid and Carbapenems interaction: clinical outcomes
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