Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis

Highlights • Epidermal Ppp6c deficiency increases susceptibility to UVB-induced SCC. • UVB-induced DNA damage is not efficiently repaired in Ppp6c -deficient keratinocytes. • Apoptosis pathway in response to UVB is activated in Ppp6c -deficient keratinocytes. • Ppp6c acts as a tumor suppressor in th...

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Bibliographic Details
Published in:Cancer letters 2015-09, Vol.365 (2), p.223-228
Main Authors: Kato, Hiroyuki, Kurosawa, Koreyuki, Inoue, Yui, Tanuma, Nobuhiro, Momoi, Yuki, Hayashi, Katsuhisa, Ogoh, Honami, Nomura, Miyuki, Sakayori, Masato, Kakugawa, Yoichiro, Yamashita, Yoji, Miura, Koh, Maemondo, Makoto, Katakura, Ryuichi, Ito, Shigemi, Sato, Masami, Sato, Ikuro, Chiba, Natsuko, Watanabe, Toshio, Shima, Hiroshi
Format: Article
Language:English
Subjects:
Animals
apoptosis
Apoptosis - radiation effects
Apoptosis Regulatory Proteins - biosynthesis
bcl-2-Associated X Protein - biosynthesis
Carcinogenesis - genetics
Carcinogenesis - radiation effects
Carcinoma, Squamous Cell - genetics
Caspase 3 - metabolism
Cell Proliferation
DNA Damage - genetics
Hematology, Oncology and Palliative Medicine
Histones - biosynthesis
Keratinocytes - metabolism
Kinases
Mice
Mice, Knockout
Mutation
p53
Phosphoprotein Phosphatases - genetics
Protein phosphatase
PUMA
Rodents
Skin - pathology
Skin - radiation effects
Skin cancer
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Proteins - biosynthesis
Ultraviolet Rays - adverse effects
UV-induced carcinogenesis
γH2AX
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Summary:Highlights • Epidermal Ppp6c deficiency increases susceptibility to UVB-induced SCC. • UVB-induced DNA damage is not efficiently repaired in Ppp6c -deficient keratinocytes. • Apoptosis pathway in response to UVB is activated in Ppp6c -deficient keratinocytes. • Ppp6c acts as a tumor suppressor in the context of UVB-induced skin cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.05.022