Acid-Catalyzed Synthesis of [alpha]-Trifluoromethylthiolated Carbonyl Compounds

The [alpha]-trifluoromethylthiolation of carbonyl compounds in soft acidic conditions has been developed. With this method only mono-trifluoromethylthiolation was selectively observed. Base-sensitive ketones can then be trifluoromethylthiolated. More sensitive aldehydes are also trifluoromethylthiol...

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Bibliographic Details
Published in:European journal of organic chemistry 2015-07, Vol.2015 (21), p.4607
Main Authors: Alazet, Sébastien, Ismalaj, Ermal, Glenadel, Quentin, Le Bars, Didier, Billard, Thierry
Format: Article
Language:English
Subjects:
Aldehydes
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Summary:The [alpha]-trifluoromethylthiolation of carbonyl compounds in soft acidic conditions has been developed. With this method only mono-trifluoromethylthiolation was selectively observed. Base-sensitive ketones can then be trifluoromethylthiolated. More sensitive aldehydes are also trifluoromethylthiolated under these conditions with good yields. This work provides a new route towards the synthesis of various valuable trifluoromethylthiolated molecules.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500710