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Anabolic steroids detected in bodybuilding dietary supplements - a significant risk to public health
Twenty‐four products suspected of containing anabolic steroids and sold in fitness equipment shops in the United Kingdom (UK) were analyzed for their qualitative and semi‐quantitative content using full scan gas chromatography‐mass spectrometry (GC‐MS), accurate mass liquid chromatography‐mass spect...
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Published in: | Drug testing and analysis 2015-07, Vol.7 (7), p.609-618 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Twenty‐four products suspected of containing anabolic steroids and sold in fitness equipment shops in the United Kingdom (UK) were analyzed for their qualitative and semi‐quantitative content using full scan gas chromatography‐mass spectrometry (GC‐MS), accurate mass liquid chromatography‐mass spectrometry (LC‐MS), high pressure liquid chromatography with diode array detection (HPLC‐DAD), UV‐Vis, and nuclear magnetic resonance (NMR) spectroscopy. In addition, X‐ray crystallography enabled the identification of one of the compounds, where reference standard was not available. Of the 24 products tested, 23 contained steroids including known anabolic agents; 16 of these contained steroids that were different to those indicated on the packaging and one product contained no steroid at all. Overall, 13 different steroids were identified; 12 of these are controlled in the UK under the Misuse of Drugs Act 1971. Several of the products contained steroids that may be considered to have considerable pharmacological activity, based on their chemical structures and the amounts present. This could unwittingly expose users to a significant risk to their health, which is of particular concern for naïve users. Copyright © 2014 John Wiley & Sons, Ltd.
24 products suspected to contain anabolic steroids and sold in fitness shops in the UK were analyzed. Most of them contained steroids including known anabolic agents, though many contained steroids that were different to those indicated on the packaging. Overall 13 different steroids were identified, 12 of these would be controlled in the UK under the Misuse of Drugs Act 1971. These included potentially hepatotoxic 17‐α‐alkylated steroids at doses that could pose a significant risk to the user's health. |
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ISSN: | 1942-7603 1942-7611 |
DOI: | 10.1002/dta.1728 |