Overexpression of eukaryotic elongation factor 1 alpha-2 is associated with poorer prognosis in patients with gastric cancer

Purpose Eukaryotic elongation factor 1 alpha-2 (eEF1A2) is a protein translation factor involved in protein synthesis. It is overexpressed in various cancers, which indicates potential vital functions in tumorigenesis and progression. Our study aims to investigate the expression levels of eEF1A2 in...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2015-07, Vol.141 (7), p.1265-1275
Main Authors: Yang, Song, Lu, Mingdian, Chen, Yuanyuan, Meng, Delong, Sun, Ruochuan, Yun, Dapeng, Zhao, Zhijie, Lu, Daru, Li, Yongxiang
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - genetics
Cancer Research
Case-Control Studies
Female
Gene Expression Regulation, Neoplastic
Hematology
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article – Clinical Oncology
Peptide Elongation Factor 1 - genetics
Prognosis
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival Analysis
Up-Regulation - genetics
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Summary:Purpose Eukaryotic elongation factor 1 alpha-2 (eEF1A2) is a protein translation factor involved in protein synthesis. It is overexpressed in various cancers, which indicates potential vital functions in tumorigenesis and progression. Our study aims to investigate the expression levels of eEF1A2 in gastric cancer and its roles in clinical practice. Methods A total of 129 patients with pathologically confirmed gastric cancer and 24 normal controls were recruited for this study. The expression levels of eEF1A2 in gastric cancer and normal tissues were evaluated by tissue microarrays, quantitative real-time PCR, and western blot analysis. Kaplan–Meier analysis and Cox’s proportional hazards model were used in survival analysis. Results Compared with corresponding controls, gastric cancer specimens had significantly increased expressions of eEF1A2 at mRNA and protein levels (both P  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-014-1897-7