Investigations of the Chemistry of Alkyl Phosphites Toward Nitrogen-Containing Compounds: Efficient Approaches to [alpha]-Amino-, [beta]-Amino-, and/or Enaminophosphonates

• Published in: Synthetic communications 2015-09, Vol.45 (17), p.1929
• Main Authors: Abdou, Wafaa M, Barghash, Reham F, Bekheit, Mohamed S
• Format: Article
• Language: English
• Subjects: Chemistry
• ISSN: 0039-7911; 1532-2432
• DOI: 10.1080/00397911.2015.1027777

In this study, we report recent investigations of the chemical reactivity of alkyl phosphites, mainly trialkyl and dialkyl phosphites, with molecules containing different nitrogen-containing compounds reported by us and other research groups over the past 25 years. Previous ground-breaking important reports are also considered. The reviewed investigations in this article are grouped according to only the type of the nitrogen-functional groups [amines (primary, secondary, and tertiary amines), imines, amides, thioamides, nitriles, isocyanates, isothiocyanates, oximes, hydrazones, diazo, and azides] and not according to the site of attack or the final products. Furthermore, the present review article focuses on the synthesis of α-amino-, [beta]-amino-, and/or enaminophosphonates. These compounds have important roles in pharmaceutical chemistry.