Facile Denitrosation of Cyclic N-Nitrosamines with Hydrazoic Acid

A simple and facile method for the denitrosation of cyclic N-nitrosamines using HN 3 (concentrated H 2 SO 4  + NaN 3 ) is reported. In this method, limited usage of this reagent does not affect the carbonyl group.

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Bibliographic Details
Published in:Synthetic communications 2015-09, Vol.45 (17), p.2030-2034
Main Authors: Ponnuswamy, S., Akila, A., Kiruthiga Devi, D.
Format: Article
Language:English
Subjects:
1,4-diazepan-5-one
Denitrosation
hydrazoic acid
piperidin-4-one
Schmidt rearrangement
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Description
Summary:A simple and facile method for the denitrosation of cyclic N-nitrosamines using HN 3 (concentrated H 2 SO 4  + NaN 3 ) is reported. In this method, limited usage of this reagent does not affect the carbonyl group.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2015.1063654