Local Angiotensin Pathways in Human Carotid Atheroma: Towards a Systems Biology Approach

We will summarize the data we have obtained in human carotid artery concerning the organization of an extended local renin angiotensin aldosterone system and its variations at different stages of atheroma. In a system view, we propose a model where concomitant increase in angiotensin and glucocortic...

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Main Authors: Bricca, Giampiero, Legedz, Liliana, Nehme, Ali, Ayari, Hanène, Paultre, Christian, Hodroj, Wassim, Li, Jacques-Yuan, Randon, Jacques, Lohez, Olivier, Dhaouadi, Nedra, Gustin, Marie Paule, Cerutti, Catherine
Format: Conference Proceeding
Language:English
Subjects:
Blood pressure
Endocrine system
Enzymes
Genomics
Hypertension
Peptides
Proteins
Smooth muscle
System theory
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Summary:We will summarize the data we have obtained in human carotid artery concerning the organization of an extended local renin angiotensin aldosterone system and its variations at different stages of atheroma. In a system view, we propose a model where concomitant increase in angiotensin and glucocorticoid signaling is induced and amplified in VSMC while vascular smooth muscle cells transdifferentiate toward a lipid storing phenotype.
ISSN:2356-6108
2356-6094
DOI:10.1155/2015/593086