Interleukin- 28B: a prognostic marker in interferon based therapy of chronic HCV patients of the Pakistan with variable treatment response

Unfortunately Pakistan carries one of the world's highest burdens of chronic hepatitis along with mortality due to liver failure and hepatocellular carcinoma. Scientists after extensive research have come up with this outcome that host genetics play a vital role in dictating the type of treatme...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2015-09, Vol.123 (9), p.765-771
Main Authors: Resham, Saleha, Manzoor, Sobia, Imran, Muhammad, Saalim, Muhammad, Naseem, Sidrah, Azam, Sikandar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - metabolism
Case-Control Studies
chronic HCV
Drug Therapy, Combination - methods
Female
Genotype
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - metabolism
Humans
IL28B
Interferon-alpha - therapeutic use
Interferons
Interleukins - genetics
Interleukins - metabolism
Male
non-responders
Pakistan
Polymorphism, Single Nucleotide - genetics
Prognosis
Ribavirin - therapeutic use
Sustained virological response
Treatment Outcome
Young Adult
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Summary:Unfortunately Pakistan carries one of the world's highest burdens of chronic hepatitis along with mortality due to liver failure and hepatocellular carcinoma. Scientists after extensive research have come up with this outcome that host genetics play a vital role in dictating the type of treatment response produced by the patients. In 2009, a genome wide association study (GWAS) revealed that genetic variants in close proximity to the IL28B (IFNL3) gene predicted greater likelihood of achieving sustained virological response (SVR) following treatment with pegylated IFN‐alpha (peg INF‐α) and ribavirin. IL28B (rs12979860 and rs8099917) single nucleotide polymorphisms (SNPs) have been recently found among the Pakistani population associated with response to chronic HCV infection INF‐α + ribavirin therapy. Therefore, this study was aimed to investigate the IL‐28B protein levels in the HCV infected patients. The findings showed that the serum IL28B protein level was higher in HCV infected patients as compared to healthy controls (7.743 ± 1.519 pg/mL versus 1.600 ± 0.06054 [mean ± SEM], p 
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12414