Three New Lignan Derivatives from Lindera glauca (Siebold et Zucc.) Blume

Two new aryl‐tetralin lignan glycosides, linderanosides A and B (1 and 2, resp.), and a new dihydrobenzofuran neolignan glycoside, linderanoside C (3), together with five known lignan derivatives (4–8) were isolated from the trunk of Lindera glauca. The structures of these new compounds were determi...

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Bibliographic Details
Published in:Helvetica chimica acta 2015-08, Vol.98 (8), p.1087-1094
Main Authors: Suh, Won Se, Kim, Ki Hyun, Kim, Ho Kyung, Choi, Sang Un, Lee, Kang Ro
Format: Article
Language:English
Subjects:
Cytotoxic activity
Lignans
Lindera glauca
Linderanosides A and B
Ovarian cancer
Sulforhodamine B (SRB) bioassay
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Summary:Two new aryl‐tetralin lignan glycosides, linderanosides A and B (1 and 2, resp.), and a new dihydrobenzofuran neolignan glycoside, linderanoside C (3), together with five known lignan derivatives (4–8) were isolated from the trunk of Lindera glauca. The structures of these new compounds were determined through spectroscopic analyses, including extensive 2D‐NMR data and acid hydrolysis. The absolute configurations of the compounds were clarified by circular dichroism (CD) spectroscopic studies. Compounds 1–8 were evaluated for their cytotoxicity against A549 (non‐small cell lung adenocarcinoma), SK‐OV‐3 (ovarian cancer cells), A498 (human kidney epithelial cells), and HCT‐15 (colon cancer cells) human tumor cell lines using sulforhodamine B assays in vitro.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201500002